Flashcards in GastroOesophageal Pathology Deck (33)
normal oesophagus epithelium cells are?
normal stomach cell types?
causes of haematemesis?
upper GIT tumour
causes of obstructive dysphagia?
3 most important cancers of oesophagus?
squamous cell carcinoma (common)
2 most important tumours of stomach
Gastrointestinal stromal tumours
oesophagus SCC risk factors, 2 major?
oesophagus SCC, why is high cell turn over bad?
more chance of errors in replication >> SCC
adenocarcinoma of oesophagus precursors? and progression?
adenocarcinoma in situ
what does reflux oesophagitis do to the oesophageal spincter?
ETOH, caffeine, preg, meds
progression of adenocarcinoma of oesophagus?
low grade dyplasia
high grade dysplais
who gets eosinophilic oesophagitis? cause? treatment?
young people with a history of allergy
looks like trachea
caused by food allergens
Rx with steroids
full Mallory-Weiss tear into mediastinum called?
causes of achalasia?
what does scleroderma do to oesophagus?
fibrosis of wall, submucosa
common tumour of stomach?
most important cause of gastric cancer?
chronic helicobacter gastritis
gastric carcinoma 2 types
intestinal - progression from helicobacter
diffuse type gastric carcinoma prognosis? and what is classic cell type?
signet ring cell carcinoma (not adhesive)
what is linitis plastica?
type of diffuse type gastric carcinoma, causing gastroparesis, 'bottle' stomach
what are low grade MALTomas?
indolent B cell lymphomas
MALTomas is found where?
localised to stomach for a long time
how to treat MALTomas?
can respond to anti helicobactor pylori treatment alone!
MALTomas left untreated?
progress to high grade lymphomas (diffuse large B-cell)
what are Gastrointestinal stromal tumours?
primary tumours of stomach
Gastrointestinal stromal tumours arrive from?
pacemaker cells of the gut (interstitial cells of Cajal)
enteric nervous system found in which layer?
Gastrointestinal stromal tumours treatment?
Imatinib to block c-kit (cell membrane bound tyrosine kinase)
predictor of Gastrointestinal stromal tumours?
larger size is more malignant
causes of gastritis?
why does helicobacter cause duodenal ulcers?
H, pylori causes increased acid secretion and can erode the duodenum
benign gastric ulcers vs. adenocarcinoma looks