Neisseria, Hemophilus, Bordetella Flashcards Preview

Pathophysiology > Neisseria, Hemophilus, Bordetella > Flashcards

Flashcards in Neisseria, Hemophilus, Bordetella Deck (26)
1

What key enzyme do Neisseria test POSITIVE for?

oxidase

2

What are 2 important growth conditions for Neisseria in the lab?

1) enhanced CO2
2) enriched media (chocolate agar)

3

Which neisseria species is a maltose oxidizer?

meningitidis

4

True or false: both neisseria species oxidize glucose?

TRUE

5

What happens to patients that have a complement deficiency defect?

6000 fold increase risk for meningococcal and gonococcal disease

6

the capsule and LPS are important to __________ while pili and OMPs are important to ___________

meningitidis
gonorrhea

7

What virulence factor is responsible for preventing phagocytosis and enhancing survival in the bloodstream?

polysaccharide capsule

8

How is meningitis transmitted?

respiratory droplets

9

What is the most common outbreak in developed world?

Group B (non vaccinatable)

10

How does N. meningitidis get to the bloodstream?

transcytoses to get into the submucosa

11

What are 2 huge infections caused by N. meningitids?

meningococcemia
meningitis

12

What do you treat N. meningitidis with?

penicillin
(ceftriaxone and other cephalosporins)

13

What are the medications for meningitidis prophylaxis?

rifampin
ciprofloxacin
ceftriaxone (1 dose)

14

What are the main antigen features of n. gonorrheae?

- pili (stacked units of repeating protein)
- PorB (porin)
- Opa (adherence proteins)
- Rmp proteins (block antibody)

15

What does the presence of Opa do to n. gonorrhea disease?

produce local disease (not disseminated)

16

Name 2 examples of antigenic variation in n. gonorrheae?

1) pili
2) opa

17

How is gonorrhea spread?

direct contact across mucosal surfaces

18

Where does disseminated N. gonorrhea go?

joints and skin

19

What is the treatment for gonorrhea?

ceftriaxone (no oral)

20

What does haemophilus cause in children under 2?

meningitis
septicemia
cellulitis

21

What does haemophilus cause in kids 2-5?

epiglottitis
pneumonia

22

What 3 infections are attributed to nontypable (aka unencapsulated) h. influenzae?

otitis media
sinusitis
bronchitis

23

How is h. influenzae diagnosed?

choc agar gram stain
needs X (hematin) and V (NAD) factor from blood

24

What are the treatments for haemophilus?

cephalosporins (2nd and 3rd) most produce beta lactamase

25

What are the main virulence factors of bordetella pertussis?

- no capsule
- adhesins
- pertussis toxin (PT)
- tracheal cytotoxin (PG fragment)

26

How is haemophilus classified? (why 3 groups?)

- serotypes
- biotypes
- biogroups