Flashcards in Neisseria, Hemophilus, Bordetella Deck (26)
What key enzyme do Neisseria test POSITIVE for?
What are 2 important growth conditions for Neisseria in the lab?
1) enhanced CO2
2) enriched media (chocolate agar)
Which neisseria species is a maltose oxidizer?
True or false: both neisseria species oxidize glucose?
What happens to patients that have a complement deficiency defect?
6000 fold increase risk for meningococcal and gonococcal disease
the capsule and LPS are important to __________ while pili and OMPs are important to ___________
What virulence factor is responsible for preventing phagocytosis and enhancing survival in the bloodstream?
How is meningitis transmitted?
What is the most common outbreak in developed world?
Group B (non vaccinatable)
How does N. meningitidis get to the bloodstream?
transcytoses to get into the submucosa
What are 2 huge infections caused by N. meningitids?
What do you treat N. meningitidis with?
(ceftriaxone and other cephalosporins)
What are the medications for meningitidis prophylaxis?
ceftriaxone (1 dose)
What are the main antigen features of n. gonorrheae?
- pili (stacked units of repeating protein)
- PorB (porin)
- Opa (adherence proteins)
- Rmp proteins (block antibody)
What does the presence of Opa do to n. gonorrhea disease?
produce local disease (not disseminated)
Name 2 examples of antigenic variation in n. gonorrheae?
How is gonorrhea spread?
direct contact across mucosal surfaces
Where does disseminated N. gonorrhea go?
joints and skin
What is the treatment for gonorrhea?
ceftriaxone (no oral)
What does haemophilus cause in children under 2?
What does haemophilus cause in kids 2-5?
What 3 infections are attributed to nontypable (aka unencapsulated) h. influenzae?
How is h. influenzae diagnosed?
choc agar gram stain
needs X (hematin) and V (NAD) factor from blood
What are the treatments for haemophilus?
cephalosporins (2nd and 3rd) most produce beta lactamase
What are the main virulence factors of bordetella pertussis?
- no capsule
- pertussis toxin (PT)
- tracheal cytotoxin (PG fragment)