Other Disorders of Hemostasis Flashcards Preview

Pathophysiology > Other Disorders of Hemostasis > Flashcards

Flashcards in Other Disorders of Hemostasis Deck (8)
Loading flashcards...
1

Why does heparin cause thrombocytopenia? (HIT)

heparin can form complex with platelet factor 4 and body develops autoantibodies to these complexes and consumes platelets

2

What is DIC?

disseminated intravascular coagulation

(abnormal activation of coag cascade - widespread microthrombi cause ischemia and infarction and decreased platelets)

3

True or false: DIC is almost always secondary to another disease process

TRUE (obstetric complication, sepsis, adenocarcinoma, acute promyelocytic leukemia, rattlesnake bite)

4

What is the best test for DIC?

D-dimer

5

What do lab findings look like for DIC?

1) LOW platelet count
2) HIGH PT and PTT
3) LOW fibrinogen
4) microangiopathic hemolytic anemia
5) elevated fibrin split products (D-dimer)

6

What is D-dimer?

an elevated fibrin split product

7

What is the final step in clot formation?

lyse the clot (product of lysing crosslinked fibrin is D-dimer)

8

What does D-dimer tell you?

that you have activated the clotting cascade so much so that you get all the way to the end of the cascade where you lyse the clot