Flashcards in Other Disorders of Hemostasis Deck (8)
Why does heparin cause thrombocytopenia? (HIT)
heparin can form complex with platelet factor 4 and body develops autoantibodies to these complexes and consumes platelets
What is DIC?
disseminated intravascular coagulation
(abnormal activation of coag cascade - widespread microthrombi cause ischemia and infarction and decreased platelets)
True or false: DIC is almost always secondary to another disease process
TRUE (obstetric complication, sepsis, adenocarcinoma, acute promyelocytic leukemia, rattlesnake bite)
What is the best test for DIC?
What do lab findings look like for DIC?
1) LOW platelet count
2) HIGH PT and PTT
3) LOW fibrinogen
4) microangiopathic hemolytic anemia
5) elevated fibrin split products (D-dimer)
What is D-dimer?
an elevated fibrin split product
What is the final step in clot formation?
lyse the clot (product of lysing crosslinked fibrin is D-dimer)