Renal Pathology II Flashcards Preview

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Flashcards in Renal Pathology II Deck (11)
1

REVIEW

What are the 3 causes of nephritic hematuria?

1) postinfectious
2) IgA
3) hereditary

2

What are the 3 causes of severe nephritic syndrome?

rapidly progressive glomerulonephritis I, II, and III

3

What is a major feature of RPGN?

crescents (severe glomerular basement membrane injury - can allow leakage of blood and fibrin into bowman space)

4

What is a glomerular crescent and why is it dangerous?

pool of blood that compresses tuft which decreases GFR (leading to rapid renal failure)

5

What two things leak into Bowman's space in glomerular crescents?

fibrin and blood

(also macrophages)

6

What are the 3 causes of pathogenesis in glomerular crescents?

1) anti-glomerular basement membrane antibody (RPGN I)
2) IC glomerulonephritis (RPGN II)
3) pauci-immune/ANCA associated (RPGN III)

7

What is the pathogenesis of RPGN type I?

anti-glomerular basement membrane antibody (anti-GBM)

8

What is the presentation of RPGN I?

1) gross hematuria (holes in BM)
2) drop in urinary output
3) hemoptysis

9

What are the classic demographics of RPGN I?

young men

10

What does RPGN look like under IF?

antibody deposited along the entire length of the glomerular basement membrane (leads to necrosis and holes in the BM --> hematuria)

11

What is Goodpasture syndrome?

autoimmune antibody cross-reactivity with pulmonary alveolar basement membrane