Flashcards in Normal Hemostasis Deck (10)
What are the 3 things required for hemostasis?
What is the first step of hemostasis?
What are the 5 steps of primary hemostasis?
1) platelet adhesion
2) shape change
3) granule release (ADP, TXA2)
5) aggregation (hemostatic plug)
What are the 4 steps of secondary hemostasis?
1) tissue factor release
2) phospholipid complex expression
3) thrombin activation
4) fibrin polymerization
What polymerizes fibrin?
What are 2 big roles of thrombin?
1) recruits and activates additional platelets
2) converts fibrinogen to fibrin
What 2 things do endothelium cells secrete to keep normal blood vessels in antithrombotic effect?
What factors are responsible for promoting the anticoagulant state?
Thrombomodulin binds to thrombin activating protein C (natural anticoagulant)
protein S = cofactor for protein C
What does antithrombin combine with to inhibit thrombin?