Normal Hemostasis Flashcards Preview

Pathophysiology > Normal Hemostasis > Flashcards

Flashcards in Normal Hemostasis Deck (10)
1

What are the 3 things required for hemostasis?

endothelium
platelets
coagulation/fibrinolysis

2

What is the first step of hemostasis?

vasoconstriction

3

What are the 5 steps of primary hemostasis?

1) platelet adhesion
2) shape change
3) granule release (ADP, TXA2)
4) recruitment
5) aggregation (hemostatic plug)

4

What are the 4 steps of secondary hemostasis?

1) tissue factor release
2) phospholipid complex expression
3) thrombin activation
4) fibrin polymerization

5

What polymerizes fibrin?

factor 13a

6

What are 2 big roles of thrombin?

1) recruits and activates additional platelets
2) converts fibrinogen to fibrin

7

What 2 things do endothelium cells secrete to keep normal blood vessels in antithrombotic effect?

prostacyclin
nitric oxide

8

What factors are responsible for promoting the anticoagulant state?

Thrombomodulin binds to thrombin activating protein C (natural anticoagulant)

protein S = cofactor for protein C

9

What does antithrombin combine with to inhibit thrombin?

heparin-like molecules

10

___________ activates the extrinsic coag cascade and is secreted by _____________

tissue factor
endothelial cells