Flashcards in Normal Hemostasis Deck (10)
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1
What are the 3 things required for hemostasis?
endothelium
platelets
coagulation/fibrinolysis
2
What is the first step of hemostasis?
vasoconstriction
3
What are the 5 steps of primary hemostasis?
1) platelet adhesion
2) shape change
3) granule release (ADP, TXA2)
4) recruitment
5) aggregation (hemostatic plug)
4
What are the 4 steps of secondary hemostasis?
1) tissue factor release
2) phospholipid complex expression
3) thrombin activation
4) fibrin polymerization
5
What polymerizes fibrin?
factor 13a
6
What are 2 big roles of thrombin?
1) recruits and activates additional platelets
2) converts fibrinogen to fibrin
7
What 2 things do endothelium cells secrete to keep normal blood vessels in antithrombotic effect?
prostacyclin
nitric oxide
8
What factors are responsible for promoting the anticoagulant state?
Thrombomodulin binds to thrombin activating protein C (natural anticoagulant)
protein S = cofactor for protein C
9
What does antithrombin combine with to inhibit thrombin?
heparin-like molecules
10
