ocd ao1 Flashcards

1
Q

what is ocd

A

A condition characterised by obsessions and/or compulsive behaviour. Obsessions are cognitive whereas compulsions are behavioural.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 main components of ocd and differences

A

Compulsion= behaviour external component(something you feel the need to do) - beh done rep to alleviate anxiety
Obsession= about cognition internal component (is something you think about.) unwanted intrusive thoughts or images that cause distress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

3 cogntive characteristics of ocd

A

Obsessive thoughts- For sufferers of OCD, these thoughts occur over and over again.
Eg: Fear of contamination, by dirt or germs; Fear of safety, by leaving doors or windows; religious fears, from being immoral; perfectionism, a fear of not being the best.

Cognitive coping strategies
sufferers of OCD adopt cognitive strategies to deal with their obsessions. For example, suffers with religious obsessions may pray over and over, to reduce their feelings of being immoral.

insight into excessive anxiety
sufferers of OCD know that their obsessions and compulsions are irrational and experience selective attention directed towards the anxiety-generating stimuli (similar to the selective attention found in phobias).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

5 emotional characteristics of ocd

A

Anxiety and distress Unpleasant emotional experiences are due to powerful anxiety which is often paired with obsessions and compulsions. These emotions are overwhelming.

Accompanying depression
the anxiety experienced can often result in a low mood and loss of pleasure in everyday activities

Guilt and disgust
Obsessions are persistent and/or forbidden thoughts and ideas, which cause irrational guilt over a minor moral issue for example or disgust directed at something external like dirt or even the sufferer themselves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

3 beh characteristics of ocd

A

Compulsions are repetitive (e.g. excessive hand washing)
sufferers will often feel compelled to repeat a behaviour

Compulsions reduce anxiety
for example, the excessive hand washing is caused by an excessive fear of germs and bacteria and is therefore a direct response to the obsession.

Avoidance
Suffers may attempt to avoid situations which might trigger compulsions. They try to manage their OCD for example, people who compulsively hand wash may avoid taking out bins or going outside where germs may be present. This can then interfere with their lives.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

3 concepts of biological explanation of ocd

A

role of genes - genetic explanation
role of neurotransmitters
role of brain structures -both neural explanations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

genetic explanations of ocd focus on

A

dentifying particular genes which are implicated in OCD.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

names of genes associated w ocd and what kind of genes are they

A

2 candidate genes
COMT genes
SERT gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ocd is described as a _______ condition

A

polygenic condiotion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

polygenic means..

A

multiple genes that might be involved with the development of OCD. whereby combination of genes that together increase vulnerability.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

research support for polygenic ocd

A

taylor 2013 suggets that there are as many as 230 genes associated w ocd after analysing previous studies
these included action of dopamine and serotonin - neurotransmitters believed to have a role in regulating mood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

role of compt gene

A

The COMT gene is associated with the production and regulation of the neurotransmitter dopamine.
One variation of the COMT gene results in higher levels of dopamine and this variation is more common in patients with OCD, in comparison to people without OCD.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

role of sert gene aka 5 htt gene

A

he SERT gene is linked to the neurotransmitter serotonin and affects the transport of the serotonin (hence SERotonin Transporter), causing lower levels of serotonin which is also associated with OCD (and depression)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

neurotransmitters involved in ocd

A

serotonin
dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

serotonin role

A

Serotonin regulates mood and lower levels of serotonin are associated with mood disorders, such as depression.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

abnormal levels of neurotransmitter serotonin may be caused by …

A

SERT gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

research support for serotonin playing a role in ocd

A

piggott et al 1990 and jenicke 1992 - antidep that increase serotonin lead to reduction in ocd symptoms whereas antidep that didnt have no effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

role of dopamine in ocd

A

higher levels of dopamine being associated with some of the symptoms of OCD, in particular the compulsive behaviours.

19
Q

structures in brain associated w ocd

A

Thalamus - responsible for safety behaviours
orbitofrontal cortex
basal ganglia
caudate nucleus

20
Q

role of ofc in ocd

A

significant role in emotions
relays info ab worries and converts emotions into actions

21
Q

ev for ofc role in ocd

A

This is supported by PET scans of patients with OCD, taken while their symptoms are active. (eg someone with germ obsession holds dirty cloth)

Cromer et al (1998) reports serotonin and dopamine are linked to these regions of the brain.

22
Q

basal gang func in ocd

A

coodination of movements
distributes serotonin and controls emotional and cog functions

23
Q

ev for basal gang func in ocd

A

Max et al. (1994) found that when the basal ganglia is disconnected from the frontal cortex during surgery, OCD-like symptoms are reduced, providing further support for the role of the basal ganglia in OCD.

24
Q

caudate nuc func

A

Caudate nucleus- acts as a filter suppresses messages from OFC

25
name biological treatments of ocd (main 2)
SSRIS - Selective serotonin reuptake inhibitors -anti dep drug stress/anxiety relif - benzodiazepines
26
How are neurotransmitters different from impulses?
The impulses send signals from the body to the brain; (electrical)​ ​neurotransmitters send signals from the brain to the body. (chemical)
27
aim of ssris
increase levels of serotonin
28
explain how serotonin works in normal ppl
serotonin is rel by presynaptic neuron into synapse where the neurotransmitter diffuses across the synapse until it reaches receptor sites on post synaptic neuron, triggers electrical impulse serotonin is reapsorbed and broken down
29
how does serotonin transmissioj differ in those w ocd
less serotonin is being rel from presynaptic neuron or serotonin reabsorbed to quickly in post synaptic neuron
30
how do ssris work
designed to block reapsorbtion of serotonin so thus increasing it levls in the synapse this means its more likley to bind to receptor sites on post synatic neuron compensating for lack of serotonin that would naturally be in th individuals system
31
structure an outline for ssris
1- what ssris are and what they aim to do 2 - how do they work 3- what is the theory behind them eg ppl w ocd rel too little or reabsorb to much serortonin so blocks reuptake and leads to normal transmission about information relating to mood 4- what is the result - red cd symptoms
32
what is benzodiazepines
anti anxiety medicatio
33
how does benzodiazepines work
increases the effect of gaba gaba has inhibitory effect -tells neurons to stop stressing
34
what is gabba
neurotransitter for natural stress inhibition
35
how does gaba work
gaba has inhibitory effect -tells neurons to stop stressing when gaba locks onto receptor site the flow of choride ions into the neuron is increased chloride ions make it more difficult for receving neuron to be stimulated by further neurotransmitters thus the nervous system is slowing down making patient feel more relaxed
36
gaba affects the flow of ______ ions
chloride ions
37
when gaba locks into receptor site the flow of choride ions into neuron in increased - what is the effect of this
more difficult for receving neuron to be stimulated by further neurotransmitters thus the nervous system is slowing down making patient feel more relaxed
38
benzodiazepies enhance gabbas effect by
bz combine w gabba receptors - chanells open more often so more chance of choride ions flowing into neuron so more -ve charged, neuron less likely to fire to increased calming effect
39
bz affect on cns and ocd
general quieting influence on cns reduction in anxiety expirenced as a result of obsessive thoughts common in ocd is reduced less obsessions - less compulsions - imporvment of symptoms
40
2 alt to ssris
tricyclics SNRIS
41
WHAT are tricyclics
older type of anti-depressant which acts on various systems including the serotonin system where it has the same effect as SSRI ​
42
dis to tricyclics
people have extreme side effects to this ​ ​
43
what are SNRIS
(serotonin -noradrenaline reuptake inhibitors) have recently been used. They are a different type of antidepressant. SNRI's increase levels of serotonin as well as other different neurotransmitter-noradrenaline.​ so effective for those who dont responf to SSRIS afer 3 months
44
gaba tells neurons to stop firing - how much % of brains nuerons responfd to gaba
40%