Flashcards in Outline of Cancer Process Deck (8)
What are the three ways cancer is caused?
How is cancer initiated?
Physical (ionising radiation/gene mechanisms)
How is cancer promoted?
Growth factors (Autocrine/Paracrine)
What is the progression mechanism of cancer?
How does cancer treatment with Avastin work?
acts as an anti-VEGF antibody (prevents tumour angiogenesis)
VEGF = vascular endothelial growth factor
What are growth factors?
- regulate cellular growth/function
- bind to cell membrane receptors
- stimulate intracellular signal transduction
GF produced locally