Outline of Cancer Process Flashcards Preview

Principles of Disease HQ > Outline of Cancer Process > Flashcards

Flashcards in Outline of Cancer Process Deck (8)
Loading flashcards...
1

What are the three ways cancer is caused?

Initiation

Promotion

Progression

2

How is cancer initiated?

Chemical carcinogens

Physical (ionising radiation/gene mechanisms)

Viral carcinogens

3

How is cancer promoted?

Growth factors (Autocrine/Paracrine)

Oncogenes

4

What is the progression mechanism of cancer?

Metastasis

5

How does cancer treatment with Avastin work?

acts as an anti-VEGF antibody (prevents tumour angiogenesis)

VEGF = vascular endothelial growth factor

6

What are growth factors?

- polypeptides
- regulate cellular growth/function
- bind to cell membrane receptors
- stimulate intracellular signal transduction
- autocrine/paracrine

7

Paracrine?

GF produced locally

8

Autocrine?

- cell carries receptors and secretes GF
- cell escapes normal control mechanism