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Flashcards in Virus Pathogenesis Deck (6)
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1

Give three mechanisms of virus pathogenesis

Cell destruction
Changes to cellular gene expression
Immunopathogenic disease (highly resistant to body's immune system)

2

Describe some features and give an example of an active infection

Highly symptomatic at the start, gradually decreases
Can be localised or widespread (viraemia)
e.g. influenza A

3

Enterovirus features/example?

Excreted in faeces
e.g aseptic meningitis/pancreatitis

4

How does a latent virus work and give an example

Infects epithelia
Migrates to ganglia
Remains latent in nuclei
Reactivated by stimuli
Migrates to epithelia where it replicates
e.g. herpes simplex 1/2

5

What is a retrovirus?

Has RNA instead of DNA
Requires an extra step for infection (reverse transcriptase)

6

How can a retrovirus induce tumors?

Infection
DNA integration
Changes in cellular gene expression
Uncontrolled multiplication
e.g. lymphomas and leukaemias