Virus Pathogenesis Flashcards
1
Q
Give three mechanisms of virus pathogenesis
A
Cell destruction Changes to cellular gene expression Immunopathogenic disease (highly resistant to body's immune system)
2
Q
Describe some features and give an example of an active infection
A
Highly symptomatic at the start, gradually decreases
Can be localised or widespread (viraemia)
e.g. influenza A
3
Q
Enterovirus features/example?
A
Excreted in faeces
e.g aseptic meningitis/pancreatitis
4
Q
How does a latent virus work and give an example
A
Infects epithelia Migrates to ganglia Remains latent in nuclei Reactivated by stimuli Migrates to epithelia where it replicates e.g. herpes simplex 1/2
5
Q
What is a retrovirus?
A
Has RNA instead of DNA
Requires an extra step for infection (reverse transcriptase)
6
Q
How can a retrovirus induce tumors?
A
Infection DNA integration Changes in cellular gene expression Uncontrolled multiplication e.g. lymphomas and leukaemias
