Psoriasis

Question 1

Example of a strong steroid

Answer 1

bethamethasone - betnovate

Question 2

Features of psoriasis presentation

Answer 2

Scaley, silvery white plaques which may be mildly to severely itchy. In severe itching the skin may develop painful cracks and fissures

Question 3

Nail psoriasis is associated with…

Answer 3

inflammatory arthritis

Question 4

Commonly associated with flexural psoriasis?

Answer 4

candida infections

Question 5

Nail psoriasis presents as…

Answer 5

pitting, onycholysis, yellowing and ridging

Question 6

Example of a mild steroid

Answer 6

hydrocortisone 1%

Question 7

Histology showing which skin disease

Answer 7

Psoriasis

Question 8

Why would oral steroids not be used in severe psoriasis?

Answer 8

may cause rebound flare up when steroids are stopped.

Question 9

Where is palmoplanter psoriasis found?

Answer 9

palms and soles of the feet - may cause painful fissuring

Question 10

Most common locations for psoriasis

Answer 10

knees, elbows, scalp

Question 11

Condition seen here

Answer 11

Psoriasis

Question 12

Example of anti-TNF agents

Answer 12

infliximab, etanercept

Question 13

In more extensive/severe psoriasis, what other treatments might be used?

Answer 13

UVB phototherapy, methotrexate, azathioprine, 6-mecaptopurine, biologics

Question 14

Conditions associated with psoriasis (6)

Answer 14

inflammatory arthritis; spondyloarthropathy; IBD; Uveitis; Coeliac disease; Metabolic syndrome

Question 15

Description of psoriasis

Answer 15

chronic, inflammatory skin condition with well-defined red and scaly plaques on the extensor surfaces

Question 16

Key immune factors in psoriasis

Answer 16

Th17, IL-1b, TNFa

Question 17

Acute form of psoriasis

Answer 17

Guttate

Question 18

Associated with streptococcal infections

Answer 18

guttate psoriasis

Question 19

Example of a very potent steroid

Answer 19

demovate

Question 20

Key disease process in psoriasis

Answer 20

epidermal hyperplasia

Question 21

What is the Koebner phenomenon?

Answer 21

new psoriatic lesions form in areas of cutaneous injury but otherwise healthy tissue; often linear in shape and not found where psoriasis may normally be found

Question 22

Onycholysis is…

Answer 22

painless separation of the nail from the nail bed often starting at the tip

Question 23

Presentation of guttate psoriasis…

Answer 23

widespread small plaques

Question 24

Guttate psoriasis is commonly associated with…

Answer 24

streptococcal infections

Question 25

Topical treatments for mild/moderate psoriasis (6)

Answer 25

coal tar, emollients, calcipotriol, steroids, calcineurin inhibitor, salicylic acid

Question 26

Peak onset for psoriasis (2)

Answer 26

15-25years; 50-60 years

Question 27

Clinical sign seen here

Answer 27

Onycholysis

Question 28

Example of a moderate steroid

Answer 28

eumovate

Question 29

Where would flexural psoriasis commonly be found?

Answer 29

in the body folds and around the genitals

Question 30

General advice for psoriasis

Answer 30

stop smoking and drinking, maintain a healthy weight