number of patients with a recurrence of skin squamous cell carcinoma in 5 years
High risk areas for skin squamous cell carcinoma to metastasize
lips and scalp
5 year survival for Breslow thickness >4mm
Examples of environmental carcinogens
coal tar, smoking, ionising radiation, arsenic, trauma
Common place for skin squamous cell carcinoma to occur
on sun exposed/damaged areas - ear, scalp, lips
Type of clothing used to avoid UV exposure
tightly woven, loose fitting, dark clothing
What is this lesion? Describe it
Squamous cell carcinoma: Small crusted nodule
What is this and describe the features?
Basal cell carcinoma: Has pearly appearance, visible vessels, small
Where does basal cell carcinoma form from?
the keratinocytes at the basal layer
What is a lenti malignant melanoma?
a slow growing carcinoma in situ found commonly in the head and neck of elderly people
Where does skin squamous cell carcinoma originate from?
the keratinocytes from the supra basal layers
How long does it take for a skin cancer to develop from a 1mm to a 4mm Breslow thickness?
6 months average
How does the skin squamous cell carcinoma present?
hyperkeratotic lump or ulcer, may be painful or bleed
Most aggressive form of melanoma
Nodular melanoma - grows vertically very quickly and metastasizes quickly
Acral Lentiginous Melanoma
Melanoma found on the palms, soles and the subungual areas - common in black and asian skin types
what is xeroderma pigmentosa?
a skin condition where there is extreme photosensitivity
precursor lesions to skin squamous cell carcinoma
Actinic keratosis; Bowens disease
What lesion is seen on this man's scalp?
Risk factors for skin cancer (7)
1. Sun exposure 2. Xeroderma pigmetosa 3. albinism 4. naevoid BCC (Gorlin's syndrome) 5. Immunosuppression (transplant patients) 6. HPV infection 7. environmental carcinogens
What is this lesion and what is it a precursor for?
Bowens disease --> squamous cell carcinoma
Risk of metastases from skin squamous cell carcinoma
Commonest form of skin cancer
Basal cell carcinoma
Mutation associated with basal cell carcinoma
description of a basal cell carcinoma
painless, slow growing lump or ulcer which can be pearly and translucent. Some may have superficial blood vessels
What type of skin cancer are renal patients more likely to get?
Squamous cell carcinoma
What is Bowen's disease?
an erythematous plaque although the cells do not originate from the epidermis
Mutation common in melanoma
Basal cell carcinoma is likely to metastasize - true or false
5 year survival for skin cancer with metastases
What is the Breslow thickness?
the thickness of a malignant skin cancer growing vertically into the epidermis/dermis