Skin Cancer Flashcards Preview

Y2 Dermatology > Skin Cancer > Flashcards

Flashcards in Skin Cancer Deck (39)
Loading flashcards...
1

number of patients with a recurrence of skin squamous cell carcinoma in 5 years

50%

2

High risk areas for skin squamous cell carcinoma to metastasize

lips and scalp

3

5 year survival for Breslow thickness >4mm

50%

4

Examples of environmental carcinogens

coal tar, smoking, ionising radiation, arsenic, trauma

5

Common place for skin squamous cell carcinoma to occur

on sun exposed/damaged areas - ear, scalp, lips

6

Type of clothing used to avoid UV exposure

tightly woven, loose fitting, dark clothing

7

What is this lesion? Describe it 

Squamous cell carcinoma: Small crusted nodule 

8

What is this and describe the features?

Basal cell carcinoma: Has pearly appearance, visible vessels, small 

9

Where does basal cell carcinoma form from?

the keratinocytes at the basal layer

10

What is a lenti malignant melanoma?

a slow growing carcinoma in situ found commonly in the head and neck of elderly people

11

Where does skin squamous cell carcinoma originate from?

the keratinocytes from the supra basal layers

12

How long does it take for a skin cancer to develop from a 1mm to a 4mm Breslow thickness?

6 months average

13

How does the skin squamous cell carcinoma present?

hyperkeratotic lump or ulcer, may be painful or bleed

14

Most aggressive form of melanoma

Nodular melanoma - grows vertically very quickly and metastasizes quickly

15

Acral Lentiginous Melanoma

Melanoma found on the palms, soles and the subungual areas - common in black and asian skin types

16

what is xeroderma pigmentosa?

a skin condition where there is extreme photosensitivity

17

precursor lesions to skin squamous cell carcinoma

Actinic keratosis; Bowens disease

18

What lesion is seen on this man's scalp?

actinic keratosis 

19

Risk factors for skin cancer (7)

1. Sun exposure 2. Xeroderma pigmetosa 3. albinism 4. naevoid BCC (Gorlin's syndrome) 5. Immunosuppression (transplant patients) 6. HPV infection 7. environmental carcinogens

20

What is this lesion and what is it a precursor for?

Bowens disease --> squamous cell carcinoma 

21

Risk of metastases from skin squamous cell carcinoma

5%

22

Commonest form of skin cancer

Basal cell carcinoma

23

Mutation associated with basal cell carcinoma

PTCH1

24

description of a basal cell carcinoma

painless, slow growing lump or ulcer which can be pearly and translucent. Some may have superficial blood vessels

25

What type of skin cancer are renal patients more likely to get?

Squamous cell carcinoma

26

What is Bowen's disease?

an erythematous plaque although the cells do not originate from the epidermis

27

Mutation common in melanoma

B-raf (50%)

28

Basal cell carcinoma is likely to metastasize - true or false

false

29

5 year survival for skin cancer with metastases

~5%

30

What is the Breslow thickness?

the thickness of a malignant skin cancer growing vertically into the epidermis/dermis