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Y2 Dermatology > Skin Immunology > Flashcards

Flashcards in Skin Immunology Deck (14)
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1

How do keratinocytes defend against pathogens? (2)

1. produce anti-microbial peptides that can directly kill pathogens
2. produce cytokines and chemokines which recruit the adaptive and innate immune system

2

What type of cell are langerhans cells?

dendritic cells

3

How do the langerhans cells act as the skins immune system?

act as an APC taking Ag and microbial fragments to the lymph nodes and activating T cells

4

T cells found in the epidermis

predominantly CD8+

5

T cells found in the dermis

CD8+ and CD4+

6

Th cells associated with inflammation include (3)

Th1, Th2 and Th17

7

Th cells associated with psoriasis

Th1 and Th17

8

Th cells associated with atopic dermatitis

Th2 and Th17

9

Cells acting as part of the immune system in the dermis

Dendritic cells, Macrophages, Neutrophils, Mast cells

10

Pre-formed mediators released by mast cells

histamine, tryptase, chymase and TNF

11

newly synthesised mediators released by mast cells

IL, TNF, Leukotrienes, PGE

12

Chromosome for MHC

Chromosome 6

13

MHC Class I features (3)

1. found on almost all cells 2. present Ag to cytotoxic T cells 3. present endogenous Ag

14

MHC Class II features (3)

1. found on APC (B cells, macrophages) 2. present to Th cells 3. present exogenous Ag