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Flashcards in Week 1 Deck (20)
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1

what is virulence?

the capacity of a microbe to cause damage to the host

2

Examples of virulence factors

adhesion, invasion, impedin, aggressin, modulin

3

Some examples of staph. aureus virulence factors

fibrinogen binding protein (adhesion), leukocidin (PVL, kills leukocytes), TSST-1 (toxin, shock, rash)

4

common skin microbiota examples

staph sp., streptococci, bacillus, candida, malassezia

5

Examples of staph. aureus conditions

Toxic shock syndrome, scalded skin syndrome

6

What is special about TSST-1 that makes it associated with toxic shock syndrome especially?

superantigens which bind a less variable area of the APC and cause a cytokine storm

7

Group A strep, b-haemolytic strep diseases?

impetigo, cellulitis, necrotising fascitis, toxic shock like syndrome

8

4 layers of the epidermis

keratin layer, granular layer, prickle cell layer, basal cell layer

9

initial formation of the epidermis has what 3 components?

periderm, basal layer

10

the epidermis forms from...

the ectoderm

11

the dermis is formed from...

the mesoderm

12

examples of appendages

hair, nails, glands, mucosae, erector pili muscles

13

why is the dermo-epidermal junction not flat?

allows for stability/strength when there is tension

14

what are Blaschkos lines?

the developmental growth pattern of skin

15

average thickness of the epidermis

1.5mm

16

major cell in the epidermis

keratinocytes

17

other cells found in the epidermis

melanocytes, langerhans cells, merkel cells

18

average turnover of skin cells in the epidermis

28 days

19

skin turnover is determined by...

growth factors, hormones, cell death

20

description of basal layer of cells

small cuboidal, one cell thick, very metabolically active