Flashcards in Week 1 Deck (20)
what is virulence?
the capacity of a microbe to cause damage to the host
Examples of virulence factors
adhesion, invasion, impedin, aggressin, modulin
Some examples of staph. aureus virulence factors
fibrinogen binding protein (adhesion), leukocidin (PVL, kills leukocytes), TSST-1 (toxin, shock, rash)
common skin microbiota examples
staph sp., streptococci, bacillus, candida, malassezia
Examples of staph. aureus conditions
Toxic shock syndrome, scalded skin syndrome
What is special about TSST-1 that makes it associated with toxic shock syndrome especially?
superantigens which bind a less variable area of the APC and cause a cytokine storm
Group A strep, b-haemolytic strep diseases?
impetigo, cellulitis, necrotising fascitis, toxic shock like syndrome
4 layers of the epidermis
keratin layer, granular layer, prickle cell layer, basal cell layer
initial formation of the epidermis has what 3 components?
periderm, basal layer
the epidermis forms from...
the dermis is formed from...
examples of appendages
hair, nails, glands, mucosae, erector pili muscles
why is the dermo-epidermal junction not flat?
allows for stability/strength when there is tension
what are Blaschkos lines?
the developmental growth pattern of skin
average thickness of the epidermis
major cell in the epidermis
other cells found in the epidermis
melanocytes, langerhans cells, merkel cells
average turnover of skin cells in the epidermis
skin turnover is determined by...
growth factors, hormones, cell death