Investigation for allergic contact dermatitis?
Distribution of atopic eczema in older children and adults
What is this condition?
Contact allergic dermatitis
Common infections associated with eczema? (2)
staph. aureus; herpes simplex virus
Difference between contact allergic and irritant dermatitis
Irritant does not require prior exposure and may occur due to milder irritants
T cells affected in eczema
Clues that allergic contact dermatitis may be workplace associated?
clears up on holiday
More extreme treatment of eczema
phototherapy, immunosuppressants and biologic agents
Appearance of eczema herpeticum
monomorphic punched out lesions
Condition where eczema and herpes simplex virus are combined
Pathogenic mechanism behind allergic contact dermatitis
langherhans cells process and present the antigen at the regional lymph nodes and activate naive CD4 T cells. This results in the production of effector and memory T cells which produce a response to future exposures within 48-96 hours.
Atopic eczema is associated with what other diseases? (3)
asthma, allergic rhinitis, food allergy
Example of emollients
Diprobase, Dermol, Epaderm, E45
Appearance of skin in a person with eczema
dry, erythematous, scaling, lichenification, excoriations
Allergic contact dermatitis requires...?
Diagnostic criteria for eczema is itching plus 3 or more of...?
visible flexural rash (children/adults), history of a flexural rash, PMH or close family history of atopy, generally dry skin, onset before age 2
raised area <0.5cm
What is this condition called?
Treatment of allergic contact dermatitis?
avoidance; topical steroids where more severe; topical calcineurin inhibitors and emollients to moisturise
Common condition associated with allergic contact dermatitis?
Localisation of a rash associated with allergic contact dermatitis?
tends to be localised to areas of exposure
Common workforces to be affected by allergic contact dermatitis?
hairdresses; beauticians; manual and farm labourers, health care professionals, cleaners, food industry workers
Discoid eczema in brief
eczema in unusual but well defined disc shape
Treatment for eczema herpeticum
IV antivirals i.e. aciclovir
Protein highly affected in eczema
Common presentation of allergic contact dermatitis
pruritis, erythema, vesicles/bullae (rare but may also have: urticaria, pustules, lichenoid lesions and ulceration)
Cytokines affected by eczema
IL - 4, 5, 13
oedema between the keratinocytes
Appearance of eczema with staph. aureus
golden crusting around infected area
Distribution of atopic eczema in young babies and infants
cheeks, scalp, extensor surfaces, neck