Psychopathology Flashcards
(107 cards)
Brief Psychotic Disorder
Psychotic Disorder
Dx requires – 1+ of the four symptoms for at 1+ day, but less than 1mo; & must include 1+ of the main three (delusions, hallucinations, or disorganized speech). 1d to 1mo
Symptoms –
* delusions
* hallucinations
* disorganized speech/derailment/tangentiality
* grossly disorganized or catatonic behavior
Tx -
Schizophreniform Disorder
Psychotic Disorder
Dx requires – 2+ of the five symptoms for 1+mo but less than 6mo; and must include 1+ of the main three (delusions, hallucinations, or disorganized speech). 1mo to -6mo
Symptoms –
* delusions
* hallucinations
* disorganized speech/derailment/tangentiality
* grossly disorganized or catatonic behavior
* negative symptoms (avolition or no motivation, alogia or limited spoken words, anhedonia or inability to experience joy)
Tx –
Schizophrenia
Psychotic Disorder
Dx requires – active phase lasting 1+ mo and includes 2 of the five symptoms and must include 1+ of the main three (delusions, hallucinations, or disorganized speech). Must also include continuous signs of the disorder for 6+ mo that may include prodromal &/or residual phases (consist of 2+ characteristics in an attenuated form or negative symptoms only) along with the required active phase.
Comorbid - anxiety, OCD, tobacco use.
Location - temporal-limbic-frontal network causes negative symptoms; striatum linked to positive symptoms; linked to hypfrontality (low activity in the prefrontal cortex)
Chemicals - +glutamate, +serotonin, +-dopamine
Symptoms –
* delusions
* hallucinations
* disorganized speech/derailment/tangentiality
* grossly disorganized or catatonic behavior
* negative symptoms (avolition or no motivation, alogia or limited spoken words, anhedonia or inability to experience joy)
*extra - 80-85% have tobacco use disorder.
Tx –
* Multimodal tx, psychosocial, FGAs + SGAs, + adjunctive meds to treat comorbidities.
* CBTp (for psychosis), cognitive remediation, ACT, assertive community tx, family psychoed, illness self-management training, social skills, supported employee services.
* SGA clozapine most effective for treatment-resistant schizophrenia (2 antipsychotic attempts at 6wks each).
* NAVIGATE team-based programs targeting high risk or early stages, includes family psychoed + individual resiliency training based on CBTp
Schizophrenia Facts
Psychotic Disorder
Etiology – the greater the degree of genetic similarity, the greater the concordance rate (likelihood that two people who share the same genes will develop the same disorder).
* Parent 6%
* Bio siblings 9%
* Child of 1 parent w/ dx 13%
* Dizygotic (fraternal) twin 17%
* Child of 2 parents w/ dx 46%
* Monozygotic (identical) twin 48%
*If an MZ twin has a child, the child has a high risk of having schizophrenia or related disorders, regardless if the child is from the affected or non-affected MZ twin. Discordant DZ twins have less likelihood of this, but more likelihood than non-affected twins.
*70-85% have comorbid tobacco use
*Psychotic symptoms 1st appear in late teens and early 30s, peak onset early-mid 20s for male + late 20s for females. Psychotic symptoms decrease w/ age, negative symptoms + cognitive symptoms persist.
Prognosis –
* better for females w/ acute & late onset of symptoms, comorbid mood symptoms (mainly depressive), mostly positive symptoms, precipitating factors, family hx of mood disorder, & good premorbid adjustment.
* patients in non-Western developing countries have acute onset, short course, and higher remission rates.
* immigrant paradox (newly arrive immigrants gave better health outcomes than more acculturated ppl in the same county w/ the same ethnicity) applies to schizophrenia & alcohol use disorder.
* anosognosia leads to nonadherence to tx + increased risk for relapse.
* patients whose family have high expressed emotion (criticism/hostility toward patient) also have increased risk of relapse.
Schizoaffective Disorder
Psychotic Disorder
Dx requires – concurrent symptoms of schizophrenia AND MDD or manic episode for majority of illness duration, but with the presence of delusions or hallucinations for 2+ wks w/o mood symptoms.
Delusional Disorder
Psychotic Disorder
Dx requires – a) 1+ delusions for 1+ mo, b) overall functioning not markedly impaired aside from the delusions.
Subtypes –
* Erotomanic (belief that another is in love with them)
* Grandiose (belief that they have great, unrecognized talent/insight)
* Jealous (belief their spouse/partner is unfaithful
* Persecutory (belief they’re being conspired against, spied on, poisoned)
* Somatic (belief involves bodily functions/sensations)
Manic Episode
Bipolar Disorder
Dx requires - abnormal, persistent elevated irritable mood, inflated self-esteem/grandiosity, + increased activity/energy, decreased need for sleep + flight of ideas for 1+ wk; also includes impaired functioning, need for hospitalization to avoid harming self/others, psychotic features.
*Geller (2002) proposed that manic-specific symptoms in 7-16y/o were elation, grandiosity, flight of ideas/ruminations, decreased need for sleep, & hypersexuality.
*Salvi (2021) proposed manic-specific symptoms in 18+ were euphoric or irritable mood, increased self-esteem/grandiosity, distracted by thoughts, decreased need for sleep w/o physical discomfort.
Hypomanic Episode
Bipolar Disorder
Dx requires - similar to manic symptoms but less severe, no functional impairment, no hospitalizations, no psychotic features, & lasts 4+ d.
Major Depressive Episode
Bipolar Disorder/Depressive Disorder
Dx requires - 5+ depressive symptoms w/ 1 being depressed mood or loss of interest/pleasure in most/all activities lasting 2+ wks, causing significant distress/impaired functioning.
Bipolar Disorders
Bipolar Disorder
Dx Requires – bipolar I: 1+ manic episode w/ 1+ major depressive or hypomanic episodes, order not important. bipolar II: 1+ hypomanic episodes & 1+ major depressive episodes. cyclothymic disorder: numerous hypomanic symptoms that don’t meet hypomanic episode criteria & numerous depressive symptoms that do no meet criteria for major depressive episodes w/ a minimum duration of 2yr for 18+, 1yr for 18-
Tx –
* psychoeducation
* interpersonal /rhythm therapy
* CBT
* family focused therapy (high expressed emotion linked to relapse)
* lithium (most effective for “classic bipolar”, no mixed episodes, no rapid cycling, long recovery between episodes, onset 15-19y/o)
* anticonvulsant drugs + SGA (most effective for “atypical bipolar”, mixed episodes, rapid cycling, lack of recovery, hypersomnia, increase appetite/weight gain, interpersonal rejection sensitivity, onset 10-15y/o)
Bipolar Facts
Bipolar Disorder
Etiology – linked to heredity, neurotransmitter/brain abnormalities, circadian rhythm irregulates (sleep/wake, hormone secretion, appetite, body temp).
Chemicals – norepinephrine, dopamine, serotonin, glutamate
Location – abnormalities in the prefrontal cortex, amygdala, hippocampus, & basal ganglia
Concordance rates –
* MZ twins 67%+
* DZ twins 20%
ADHD
Neurodevelopmental Disorder
*adult ADHD includes labile, dysphoric mood, reduced self-esteem, distracted by wandering (not rumination), fatigue, + discomfort w/ loss of sleep.
MDD
Depressive Disorder
Dx requires – 5+ symptoms, 1 must include depressed mood or loss of interest/pleasure in activities, for 2+ wks.
Etiology -
age
* young adults linked to genetics, life stressors, + limited problem solving/cognitive abilities.
* older adults linked to chronic illness, especially if it decreased psychical functioning & leads to social isolation.
* older adults are less likely to refer to affective symptoms & more likely to refer to somatic symptoms, cognitive changes, & loss of interest in activities.
culture
* Latinx, Mediterranean, Middle Eastern, Asian, & non-Western cultures report more somatic symptoms.
* Western cultures report more psychological symptoms.
Comorbidity –
* mostly linked with substance use (mostly alcohol), then anxiety, then personality
* sleep abnormalities, prolonged latency (linger initiation), reduced REM + slow-wave, increased REM density (more eye movements per unit of time)
* coronary heart disease, stroke, diabetes, Parkinson’s
* can be bidirectional in causality of heart attacks (myocardial infarction)
Tx -
* psychotherapy, psychopharm (equal), & a combination (more effective)
* St. John’s Wort has similar effects as SSRIs; helpful for mild-moderate, but can cause serotonin syndrome when taken w/ SSRI & can decrease drug effects when taken w/ alprazolam/Xanax or bupropion/Wellbutrin.
* Ketamine/Esketamine (used since 1960s) nose spray is fast-acting tx for treatment resistant depression + SI; it increased glutamate & is used w/ an oral antidepressant
* ECT & rTMS
* telepsychotherapy; similar effects to face-to-face
* children: insufficient evidence to recommend a specific tx
* adolescents: CBT, interpersonal psychotherapy for adolescents (IPT-A), fluoxetine/Prozac but insufficient evidence to recommend one tx over another.
* adults: MCBT, IPT, behavior, psychodynamic, & supportive therapy, or second-gen antidepressants (SSRI or SNRI); strong recommendation for combined tx of CBT or IPT plus second-gen antidepressant
* older adults: recommended either group-CBT or combo of IPT & second-gen antidepressant; insufficient evidence for bibliotherapy or life review therapy
Persistent Depressive Disorder
Depressive Disorder
Dx requires – 2+ symptoms (poor appetite/overeating, insomnia/hypersomnia, hopelessness), 1 must include depressed mood, for 2+ yrs 18+ or 1yr+ 18-
Disruptive Mood Dysregulation Disorder
Depressive Disorder
Dx requires – 1+ on a) severe/recurrent overreactive temper outbursts (verbal or behavioral) occurring 3+x/wk; b) persistently irritable/angry mood for most of the day, nearly every day between outbursts.
Depressive Disorders Specifiers
Depressive Disorder
Specifier: peripartum onset(during pregnancy or 4wks after delivery)
* 80% of women experience “baby blues” after birth
* 9% of women experience major depressive episode between conception & birth
* 7% of women experience major depressive episode between birth – 1yr postpartum
Specifier: seasonal pattern (mood correlates w/ time of yr; also known as SAD)
* symptoms include hypersomnia, overeating eating, weight gain, craving carbs
* low serotonin levels, high melatonin
* Tx – phototherapy (light exposure)
Depression Disorder Facts
Depressive Disorder
Etiology – linked to heredity, neurotransmitter/brain/hormone abnormalities, & cog/behavior factors (Lewinsohn’s Social Reinforcement Theory; Seligman’s Learned Helplessness; Beck’s Cogntive Theory).
Chemicals - -serotonin, -dopamine, -norepinephrine
Location – abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis (early life stress w/ hypersecretion of cortisol); prefrontal cortex (high activity in the ventromedial prefrontal cortex [vmPEC] + low activity in the dorsolateral prefrontal cortex [dlPFC])
Concordance rates –
* MZ twins 50% for unipolar depression
* DZ twins 20% for unipolar depression
* MZ female twins 50%
* DZ female twins 34%
* MZ male twins 40%
* DZ male twins 28%
*Depressive rates for females increase in early adolescence & persists into adulthood, rates for males remains stable over time; theory is that puberty hormones sensitized females & desensitizes males of negative life stressors. female adolescents + adults have 1.5 – 3x higher depressive rates than male adolescents + adults.
Electroconvulsive Therapy
ECT
Depressive Disorder
Treats Major Depressive Disorder
Pros –
* successful w/ severe depression + SI,
* higher response (80%) & higher + faster remission (70%) than psychotherapy (30-60%) & psychopharm (25-45%).
* produces remission w/i 1-3wks, IPT/CBT 6-10wks, antidepressants 4-12wks.
Cons –
* anterograde (resolves w/i 2wks) & retrograde amnesia (resolves w/i wks to mos, older memories return first)
Repetitive Transcranial Magnetic Stimulation
rTMS
Depressive Disorder
noninvasive technique using magnetic fields to stimulate the left dorsolateral prefrontal cortex; mostly used for treatment-resistant depression.
Pros -
* doesn’t require sedation nor cause memory loss.
Cons -
* lower response + remission rates than ECT
Suicide Rates
Depressive Disorder
- US 2000-2018 increased; decreased 2018-2020
- consistently higher for males than females; in 2000-2020 being 3-4x higher for males
- 2020 was the highest for 75y/o+ & Native Americans/Alaskans, followed by (in order) White, Hispanics, Blacks, & Asian/Pacific Islanders.
- 2020 highest rates for males 75y/o+, highest rates for females 45-64y/o
- 2020 highest for Native Americans/Alaskans, Hispanics, & Blacks ages 25-34y/o; highest for Whites ages 45-54; highest for Asian/Pacific Islanders ages 85+
Separation Anxiety Disorder
Anxiety Disorder
described as developmentally inappropriate/excessive fear/anxiety about being separated from attachment figure. Often develops after exposure to stressful event (parental divorce, death or relative or pet).
Dx requires – 4+ wks in children/adolescents, 6mos in adults; must cause significant distress or impaired functioning.
Symptoms –
* Excessive distress relating to separation from attachment figures
* Persistent reluctance to go to school, work, places away from home
* Repeated complaints of physical symptoms when separated
Tx –
* CBT + psychoed, exposure, relaxation techniques + cognitive restricting; increased effectiveness when CBT is combined w/ parent training.
* if school refusal is part of the disorder, initial tx goal is school attendance to avoid social isolation, academic failure, & other secondary impairments
*School refusal can be linked to social anxiety & other anxiety disorders
Specific Phobia
Anxiety Disorder
Intense fear/anxiety about a specific object/situation, accompanied by avoidance or endurance w/ intense distress. Mowrer’s (1947)
Dx requires – fear/anxiety must be disproportionate to actual danger, persistent for 6+ mo, & cause significant distress/impaired functioning. Specifiers are used to indicate type (animal, environment, blood-injection-injury, situational, other).
Symptoms –
* Specific phobias 2x more common in girls than boys; onset usually in childhood or by age 10.
Tx –
* Exposure + response prevention to extinguish conditioned anxiety response; two types of exposure that can be done in vivo or in imagination: flooding (immediate exposure lasting until the fear subsides) and graded (listing 10 related anxiety-provoking things from least to most fearful and gradually being exposed to the an increasingly fearful list-item; ex: standing on a chair, on a ladder, and then a roof)
Social Anxiety Disorder (Social Phobia)
Anxiety Disorder
Dx requires – fear/anxiety a social situation and either avoids it or endures with extreme fear/anxiety; must be disproportionate to actual danger, persistent for 6+ mo, & cause significant distress/impaired functioning.
Tx –
* CBT + antidepressants (SSRI + SNRI) first-line tx
* Internet driven CBT is found to be equally effective for adults as face-to-face
* School-based CBT is found to be effective for children/adolescents
Panic Disorder
Anxiety Disorder
Dx requires – unexpected panic attacks w/ 1+ attack followed by 1mo+ of persistent concern about future attacks or consequences &/or significant maladaptive behavior related to the attack; involves 4+ of the 13 symptoms.
Symptoms –
* heart palpitations, sweating, nausea/abdominal distress
* dizziness, fear of losing control/going crazy
* derealization/depersonalization
* paresthesia (burning/prickling sensation)
Symptoms are similar to hyperthyroidism, cardiac arrhythmia, & other medical conditions so those need to be ruled out first.
Tx –
* CBT
* Panic Control Treatment (interoceptive exposure: exposing patient to physical symptoms of panic attack & paired w/ relaxation techniques for controlling symptoms; ex: breathing through a straw, running in place)
* Antidepressants (imipramine) + benzodiazepines (high relapse rate when drugs are used as only tx)