Flashcards in Set 3 Deck (50)
Ash leaf spots, cardiac and kidney tumors, seizures / developmental delay?
Tuberous Sclerosis (mutation in 2 tumor suppressor genes)
Lens dissociaton associated with (2)
homocysteinuria = downward
Marfan's = upward
AMS, ataxia, nystagmus and conjugate gaze palsy
Wernicke's encephalopathy (B1 thiamine def)
Pathogenesis of statin-induced myopathy
inhibits intracellular coenzyme Q10 synthesis
Pathogenesis of RHF in COPD patient
pulmonary HTN from chronic hypoxemia --> constriction of pulmonary arterial system
What do prolonged QRS vs. prolonged QT indicate?
QRS = bradyarrhythmia (BBB)
QT = tachyarrhythmia (subtype of Vtach)
Tx Dressler's Syndrome
NSAIDs > > corticosteroids
Thiamine 1st then dextrose, naloxone and O2
2 causes of pulsus paradoxus
I.e. drop in SBP >10 during Inspiration
1. Cardiac tamponade
2. Severe asthma/COPD
(during inspiration blood pools in the lungs --> decreased LV preload --> decreased CO)
Complications of Strep Pharyngitis vs. Impetigo?
Strep pharyngitis can lead to PSGN, rheumatic fever, scarlet fever
Impetigo can only cause PSGN
ST depression V1 and V2
Posterior wall MI
Dx, Tx heat stroke
Tx evaporative cooling (water spray / fans)
Nifedipine (dihydropyridine CCB)
2 major causes of pseudotumor cerebri?
Vit. A toxicity (isotretinoin or prolonged tetracylcine use), OCPs
Tx depression WITH insomnia
Exudative (increased protein) effusion withOUT evidence of infection
Malignancy --> BCA or Lung MC
2 cardiac problems where Mg sulfate is the Tx
Torsades and digoxin OD
Pathogenesis of hyperprolactinemia
decreased DA in hypothalamus/tuberoinfundibular pathway --> LOSS of normal inhibition on PRL release from ANTERIOR pituitary. Hence, see increased PRL in patients on antipsychotics (DA antagonists)
Immune response elicited by Pneumoccocal polyvalent (subunit) vaccine
B cell only b/c polysaccharides* can't be presented to T cells (peptides and proteins can be though)
Decreased grip --> nerve injured
ulnar --> INTEROSSEOUS muscles
Tx asystole or PEA
CPR --> epinephrine
DO NOT SHOCK unless in vfib or pulseless vtach
HTN, hematuria and abd mass in a young person, think? associated with? (2)
PKD (autosomal dominant)
a/w cerebral aneurysms and strokes
3 DA pathways and ass. conditions
mesolimbic - excitatory - schizophrenia (incr. DA)
tuberoinfundibular - inhibitory - hyperPRL (decr. DA)
nigrostriatal - inhibitory - parkinsonism (decr. DA)
JVD, Kussmaul's sign, hypotension, clear lung fields and NORMAL heart sounds (not muffled)? Tx?
RHF (vs. cardiac tamponade w/ muffled heart sounds).
Tx = IVF to sustain preload and BP, avoid nitro or diuretics
What is injured with fx of supracondylar region of humerus?
median nerve and/or brachial artery
Child with syncope and hearing impairment? Tx?
QT prolongation syndrome - often + FHx
Tx BB +/- pacemaker if sx
BB or CCB
decreased radial pulses that disappear with deep inspiration?
pulsu paradoxus --> cardiac tamponade
RF for AAA, oeprative criteria
RF = age >60, SMOKING, fhx, atherosclerosis
(****NOT HTN which is RF for aortic dissection)
Operate if >5.5cm, symptomatic or rapidly expanding