TEST #4 Pharmacology part II 11/29/16 Dr. Flekenstein Flashcards Preview

Biochem Human Form and Function > TEST #4 Pharmacology part II 11/29/16 Dr. Flekenstein > Flashcards

Flashcards in TEST #4 Pharmacology part II 11/29/16 Dr. Flekenstein Deck (43):
1

T/F
The concentration of a drug at a particular site is not related to its affinity

False
It is related to its affinity

2

The initial distribution of drug into tissues is determined by what?

Rate of blood flow

3

What is a topical drug?

-A drug that is applied to a surface

4

T/F
Plasma binding proteins and gastric emptying time can play a role in the effect of a drug

True

5

What is transdermal administration?

-A patch that releases slowly

6

What is a synonymous term for therapeutic range?

-Therapeutic window

7

What is a substance that brings about a change in biologic function through its chemical actions?

-Drug

8

What is a subset or compound of drugs used for selective, therapeutic effects?

-Medicine

9

What are chemicals not synthesized in the body?

-Xenobiotic

10

What is it called when you have unintended effects from a drug?

-Side Effect

11

What are four factors that effect the absorption of drugs in the blood?

-Route of administration
-Blood flow
-Drug characteristics
-Cell membrane characteristics

12

What are four important characteristics of drugs that deal with membrane diffusion?

-Whether the drug is lipid soluble or water soluble
-size (large vs small)

13

T/F
Formulation, concentration and acidity are all important considerations to make when looking at drug characteristics.

True

14

What type of drugs are only soluble in lipids?

-non-ionized drugs

15

What is the fraction of unchanged drug reaching the systemic circulation following administration by any route?

-Bioavailability

16

If you do an intravenous injection what is your bioavailability?

-100%

17

What can effect bioavailability of a drug?

-Drug dissolving in GI tract
-Drug destruction by liver

18

What is the measure of the apparent space in the body available to contain a drug?

-Volume of distribution

19

How do you measure the volume of distribution?

-V= Amount of drug in body / concentration

20

If you have a Vd of 3 L what does that mean?

-Drug stayed mainly in the plasma

21

If you have a Vd of 14 L what does that mean?

-Drug was distributed into the extracellular space

22

If you have a Vd of 42 L what does that mean?

-Drug was distributed into all of the total body water

23

If you have an extremely high Vd such as 300 L what does that mean?

-The drug has accumulated into the fat

24

If you have drugs with small volume of distribution what does that mean?

-Drugs are limited to certain areas within the body

25

If you have drugs with a large volume of distribution what does that mean?

-The drug penetrates extensively into tissues throughout the body

26

What do you use to calculate half life?

-Volume of distribution

27

What is clearance of a drug?

-Rate of elimination

28

How are drugs generally eliminated?

-Urine

29

What are four places in the body that SLC and ABC transporters are used?

-Small intestine
-Liver
-Kidney
-Brain capilaries

30

What do p-glycoproteins do?

-Transport drug molecule from cells back into the intestinal lumen for excretion

31

What order of drug is it if a constant amount of drug is eliminated per unit time?

-Zero order

32

T/F
Zero order drug is a process that takes place at a constant rate independent of drug concentration involved in process

True

33

What order of drug is it when the process that is directly proportional to the drug concentration involved in process?

-First order

34

What does metabolism of a drug mean?

-A change in the drug

35

When you metabolize drugs what happens to its activity?

-Generally goes inactive but can sometimes become more active

36

What does Phase I of hepatic metabolism mean?

-Oxidation
-Reduction
-Hydrolysis

37

What type of phase I metabolites are excreted?

-Hydrophilic metabolites all others go to phase II

38

T/F
Cytochrome p450 is associated with microsomes

True

39

What is a key molecule for drug metabolism (oxidation), biotransformation, and detoxification?

-Cyto p450

40

When you have something that increases the activity of a particular p450 enzyme and thus increases metabolism and clearance of a drug what is that called?

-Inducer

41

When you have something that inhibits the activity of a particular p450 enzyme and thus decreases metabolism and clearance of a drug what is that called?

-Inhibitor

42

What occurs in phase II of hepatic metabolism?

-Conjugation that makes the drug more hydrophilic

43

What are the seven types of conjugation found in phase II?

-Glucuronidation
-Acetylation
-Glutathione
-Glycine
-Sulfation
-Methylation
-Water