Thrombosis and risk factors for thrombosis (haematology pathology) Flashcards Preview

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Flashcards in Thrombosis and risk factors for thrombosis (haematology pathology) Deck (14):
1

what are the 3 factors of thrombosis?

1) Blood flow
2) Blood composition
3) Vascular endothelium

2

Describe arterial thrombus formation

1) rupture of atheromatous plaques
2)Endothelial injury
3) Platelet aggregation leads to occlusion

3

What are the risk factors of thrombosis?

1) smoking
2) hypertension
3) hypercholesterolaemia
4) Diabetes
5) family history
6) Obesity
7) Physical inactivity
8) age
9) male

4

What is the pathogenesis of venous thrombosis?

1) Venous stasis
2) Hypercoagulable state

5

"Thrombi are mostly composed of fibrin with a lesser role for platelet accumulation and aggregation" - Is this venous / arterial thrombus?

Venous thrombosis

6

What are the risk factors of VTE?

-active cancer treatment
- age over 60 years
- dehydration
- surgery
- oestrogen containing contraceptive
- obesity
-immobility
- pregnancy

7

Name some anticoagulant factors?

-Protein C
-Protein S
-Anti-thrombin III
-Fibrinolytic system

8

What is thrombophilia?

Thrombophilias are familial or acquired disorders of the haemostatic mechanism which are likely to predispose to thrombosis

9

What are the heritable thrombophilias?

-Antithrombin deficiency
-Protein C deficiency
-Protein S deficiency

10

what type of thrombophilia is acquired thrombophilia?

Antiphospholipid syndrome

11

What are the clinical features of thrombophilia?

1) DVT
2) PE
3) superficial thrombophlebitis
4)Thrombosis of cerebral, axillary veins.
5) Arterial thrombosis

12

What is the most common familial thrombophilia?

Factor V Leiden

13

What inherited condition causes increased prothrombin levels?

Prothrombin 20210A

14

Antiphospholipid Syndrome

isorder of the immune system that causes an increased risk of blood clots.

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