Flashcards in Toxicology 2 Deck (78)
With chronic alcohol abuse, what happens to coagulation?
defect-- decreased coagulation proteins
With chronic alcohol abuse, what happens to our CNS?
memory loss, dementia, cerebellar atrophy,
With chronic alcohol abuse, what happens to our nerves?
With chronic alcohol abuse, what happens tour AST and GGTP, triglycerides?
They go up
With chronic alcohol abuse, what happens to glucose tolerance?
impaired glucose tolerance and diabetes mellitus (pancreatic injury)
With chronic alcohol abuse, what happens to plasma magnesium and phosphate?
With chronic alcohol abuse, what happens to plasma uric acid?
With chronic alcohol abuse, what happens to plasma folate?
goes down, megaloblastic anemia
What are the 2 types of tolerances to chronic alcohol consumption?
metabolic and neuronal
Is fatty liver reversible?
yes from a good diet and strict abstinence
What are the major complications of liver cirrhosis?
1. portal hypertension (varicose and hemorrhoids)
2. salt and water retention (ascites, edema
What are the major problems of liver transplantation in alcohol abusers?
2. other organ problems
4. new liver endangered if not abstinence
What are the 3 multifactorial risks to fatty liver?
genes, environment, alcohol
What tells us we are alcoholic hepatitis?
only medium high AST levels for months
What happens to NAD and OAA in alcoholism?
concentration is decreased by EtOH oxidation--this might lead to the decreased F.A. oxidation and increased fatty liver
Acute intoxication reduces metabolizing activity?
does Long term alcohol use increase or decrease microsomal enzyme activity? which enzymes? What about when it finally reaches cirrhosis?
2. CYP2E, CYP3A
3.overall metabolism reduced
aspirin and Etoh leads to what?
Are effects of CNS depressants and vasodilators and anti-coagulants exaggerated with alcohol?
is there increased gastric uptake of penicillin with EtOh?
What are 5 things FAS children have?
smaller heads and brains
abnormal facial features
Alcoholism is a disease that includes what 4 symptoms?
loss of control
How many alcohol abusers are in the US? how much of the annual health expenditure? how many deaths?
What 3 races had the most alcoholics of persons greater than 11?
american indian> native hawaiian or islander>hispanic
What age group has the highest alcohol abusers?
18-25> 26-34> 35-49
When do seizures during alcohol withdrawal occur?
days 1-3 with minor symptoms
What are minor symptoms of alcohol withdrawal?
What are the major symptoms of alcohol withdrawal?
What is disulfiram?
aldehyde dehydrogenase inhibitor used to support alcoholism