Flashcards in Toxicology 2 Deck (78)
What is naltrexone used for in alcoholism?
opioid receptor antagonist--> inhibits desire for alcohol.
Should we use anti-depressants to treat alcoholism?
What is a dangerous alcohol with therapeutic use, flammable, hydroxyl derivative, miscible with water CNS depressant?
What is a dangerous alcohol without therapeutic use, flammable, hydroxyl derivative, miscible with water CNS depressant?
What is the 2nd most freq ingested alcohol?
What are the kinetics of isopropanol?
rapid, metabolism to acetone, slow elimination in kidneys and lung (acetone breath)
How potent is isopropanol a CNS depressant as EtOH?
twice- >3 swallows by a child contact health care
Should we use EtOH as an antidote for isopropanol?
Where can we find methanol?
antifreeze, paint remover
Can methanol be absorbed through skin and lung exposure?
How is methanol metabolized?
hepatic--to formaldehyde and formic acid
how much of methanol is needed to cause blindness?
10 ml of 40%
What correlates best with lethality of methanol?
Is ethylene glycol bitter?
no it is sweet> sweet man's alcohol
[from antifreeze and coolant]
What is ethylene glycol metabolized to/
What does ethylene glycol do to kidneys?
leads to failure and crystals in renal tubules (where it is filtered and reabsorbed)
What is a major problem of ethylene glycol in the body?