Unit 3- Mycoplasma

Question 1

PPLO

Answer 1

Pleuropneumonia-like organisms

Question 2

Mycoplasma

Answer 2

Pleiomorphic shape, lack cell wall, electron dense core terminal, motile

Question 3

Core Terminal

Answer 3

At one end of the cell, allows attachment onto host cells, gliding motility, cell division

Question 4

Mycoplasma Enzymes

Answer 4

RNA polymerase makes them prone to mutation

Question 5

Mycoplasma Cell Surface

Answer 5

Glycolipids, lipoglycans, lipoprotein, capsule, host derived cholesterol, adhesins

Question 6

Mycoplasma Secretion

Answer 6

H2O2, superoxide, nuclease, immunoglobulin protease, antioxidant enzymes, sialidases, hyaluronidases

Question 7

Mycoplasma Culture

Answer 7

Slow fastidious growth, mycoplasma selective media

Question 8

Mycoplasma Agar

Answer 8

Beef heart, yeast autolysate, nucleic acid precursors, penicillin to prevent gram positive, thallium acetate to prevent gram negative, serum

Question 9

Mycoplasma Growth on Agar

Answer 9

Slow growing allows for chronic disease, gliding motility gives fried egg appearance

Question 10

Small Colony

Answer 10

Mycoplasma mycoides subsp mycoides infecting cattle

Question 11

Large Colony

Answer 11

Mycoplasma mycoides subsp mycoides infecting goat

Question 12

Mycoplasma Virulence Factors

Answer 12

Cell surface molecules for antigen variation and mimicry, secreted enzymes, manipulation of host cells, parasitism outside host cells

Question 13

Capping

Answer 13

Incorporation of host antigens into Mycoplasma

Question 14

Mycoplasma Infection

Answer 14

Elicits inflammation, MAKePSR syndrome, cancer, autoimmunity

Question 15

Mycoplasma Cancer

Answer 15

Inhibits P53 tumor suppressor protein

Question 16

Intracellular Mycoplasma

Answer 16

Change host cell morphology and genetics, cause cancers

Question 17

Extracellular Mycoplasma

Answer 17

Intimately attached to membrane surface

Question 18

Mycoplasma Transmission

Answer 18

Airborne, contact, sexual, ingestion, transovarian in birds

Question 19

Mycoplasma Tropism

Answer 19

Infects mucosal tracts and other body parts in all vertebrates with some host specificity

Question 20

MAKePSR Syndrome

Answer 20

Mastitis, arthritis, keratoconjunctivitis, pneumonia, septicemia, reproductive disorder

Question 21

Bovine Mycoplasma Species

Answer 21

Mycoplasma bovis and mycoides subsp mycoides small colony variant

Question 22

Bovine Mycoplasma Symptoms

Answer 22

Arthritis, extended neck with legs far apart, coughing, ocular and nasal discharge, pleural fluid, thickening of lung, lung adherence to chest wall

Question 23

CBPP

Answer 23

Contagious bovine pleuropneumonia, can cause a trade ban

Question 24

CCPP

Answer 24

Contagious caprine pleuropneumonia, can cause a trade ban

Question 25

Sheep and Goat Mycoplasma Species

Answer 25

Mycoplasma agalactiae, capricolum, mycoides, ovipneumonaie

Question 26

Sheep and Goat Mycoplasma Symptoms

Answer 26

Mastitis, mammary atrophy, high fever, cough, wide stance, granular lung

Question 27

Swine Mycoplasma Species

Answer 27

Mycoplasma hyopneumoniae, hyorhinis, and hyosynoviae

Question 28

Swine Mycoplasma Symptoms

Answer 28

Lung hepatization, cranioventral lung consolidation, collapse of lung lobes

Question 29

Poultry Mycoplasma Species

Answer 29

Mycoplasma gallisepticum, synoviae, and meleagridis

Question 30

Poultry Mycoplasma Symptoms

Answer 30

Airsacculitis, sinusitis, swollen sinuses, periorbital swelling, swollen foot, arthritis

Question 31

Horse Mycoplasma Species

Answer 31

Mycoplasma felis, equirhinitis, equipharyngis

Question 32

Horse Mycoplasma Symptoms

Answer 32

Pleuritis

Question 33

Pet Mycoplasma Species

Answer 33

Mycoplasma cynos and felis

Question 34

Pet Mycoplasma Symptoms

Answer 34

Pneumonia, conjunctivitis

Question 35

Haemobartonella canis

Answer 35

Mycoplasma haemocanis, causes severe hemolytic anemia in dog

Question 36

Haemobartonella felis

Answer 36

Mycoplasma haemofelis, causes severe hemolytic anemia in cat

Question 37

Mycoplasma Pathology

Answer 37

Thickening and fibrosis of lung, hepatization of lung, marbling, granuloma, necrotic encapsulated lesions, straw colored fluid on thoracic cavity, enlarged joints

Question 38

Iceberg Concept

Answer 38

High mortality, high morbidity, recovered animals can be carriers

Question 39

Mycoplasma Diagnosis

Answer 39

Fried egg colonies on agar, serology, PCR

Question 40

Mycoplasma Treatment

Answer 40

Intrinsic drug resistance, sequestration in granuloma, cull infected animals