Viral hepatitis

Question 1

What route is hep a transmitter

Answer 1

Oro faecal

Question 2

Where is Hep A more common

Answer 2

In countries where access to clean water is poor

Among MSM

Question 3

What is incubation period for Hep A

Answer 3

2-6 wks

Question 4

What are symptoms for hep a

Answer 4

jaundice
malaise
RUQ discomfort

Question 5

What is the type of disease that Hep A causes

Answer 5

ACUTE (either resolves or people die)

Question 6

WHAT does a HEP A + person show on investigation

Answer 6

HIGH IgM

high ALT

Question 7

What does a Hep A vaccinated person show on ix

Answer 7

High IgM, IgG

Normal ALT

Question 8

What is the illness course of Hep B

Answer 8

acute > chronic / resolves

Question 9

What is the surface antigen of Hep B

Answer 9

HBsAg

Question 10

What is the core antigen of hep B

Answer 10

HBcAg

Question 11

What antigens do you have ONLY if you HAVE Hep B (rather than vaccine)

Answer 11

HBcAg

HBeAg

Question 12

What is the marker of Hep B immunity

Answer 12

HBsAb

Question 13

What are you positive for if you’ve had Hep B vaccine

Answer 13

HBsAb // anti-Hbs

Question 14

When does anti-HBs form

Answer 14

last antibodies to form after resolution of infection

OR

formed by vaccine

Question 15

What are you positive for if you have acute HBV infection

Answer 15

+ HBsAg, Anti-HBc IgG, Anti-HBc IgM

Question 16

What are you positive for if you have chronic HBV infection

Answer 16

+ HBsAg, Anti-HBc IgG

Question 17

What are you positive for if you have resolved HBV infectioon

Answer 17

+ antiHBc IgG, anti-HBs

Question 18

What is the worse consequence of HBV

Answer 18

Hepatocellular carcinoma

Question 19

How do you treat chronic HBV ?

Answer 19

Pegylated interferon alpha

Nucleotide analogues e.g. TENOFOVIR, ENTECAVIR

Question 20

What is the course of HCV?

Answer 20

Acute infection > high likelyhood to become chronic

Question 21

What is the incubation period for HCV

Answer 21

6-8 weeks

Question 22

How do you detect HCV in blood

Answer 22

HCV RNA

Question 23

What do you detect if someone has HDV

Answer 23

IgM anti-HDV

Question 24

When does HDV infection occur

Answer 24

ONLY with confection with hep B

Question 25

What do you detect if someone has HEV

Answer 25

IgM anti-HEV, IgG

Question 26

What do you detect if someone is immunocompromised with HEV

Answer 26

HEV RNA

Question 27

What do you detect if someone is HEV positive with chronic infection

Answer 27

HEV RNA for more than 3 months