Antimicrobials 2

Question 1

What are the two ideal traits for antibiotics

Answer 1

narrow spectrum

bactericidal

Question 2

what is MIC

Answer 2

minimum inhibitory concentration

Question 3

What should you do for Type 1 concentration dependent drugs

Answer 3

Peak above MIC is the most important fasctor > give ONE DOSE ONCE A DAY to try and get that peak as high as possible
but balance it out with adverse effect

Question 4

What should you do for Type 2 time dependent drugs

Answer 4

maximise TIME above MIC

so take them very frequently

Question 5

What is a Type 1 concentration dependent drugs

Answer 5

aminoglycoside

Question 6

What is a Type 2 time dependent drug

Answer 6

Penicillin

Question 7

What is vancomycin

Answer 7

combination of TI and TII

Question 8

How do you treat skin infection and why

Answer 8

flucloxacillin

because common organisms are staph A and beta haemolytic strep

Question 9

What is the best antibiotic for Group A strep invasivee

Answer 9

clindamycin

Question 10

How do you treat pharyngitis

Answer 10

benzylpenicillin 10 days

Question 11

how do you treat CAP mild

Answer 11

amox

Question 12

how do you treat cap sever

Answer 12

co-amoxiclav + clarythromyci

Question 13

how do you treat bacterial meningitis

Answer 13

ceftriaxone

Question 14

When do you consider adding amoxicillin for bacterial meningitis

Answer 14

if listeria is likely

Question 15

What antibiotics do you give for bacterial meningitis in baby

Answer 15

cefotaxime + amox

Question 16

antibiotic for simple cystitis

Answer 16

Trimethoprim 3 days

Question 17

antibiotic for hosp aquired UTI

Answer 17

cephalexin OR augmentin

Question 18

antibiotic for infected urinary cath

Answer 18

gentamicin

Question 19

How do you treat c diff colitis

Answer 19

Stop offending antibiotic (usually cephalosporin)

If severe, give metronidazole / vancomycin PO