Pyrexia Unknown Origin

Question 1

What is a fever of unknown origin

Answer 1

Fever >38.3 lasting >3 weeks with uncertain dx after 7 days in hospital

Question 2

What criteria can you use for PUO

Answer 2

Durack and STreet

Question 3

What cateories are included in the DUrack and Street criteria

Answer 3

Classic, nosocomial, immune deficient, HIV

Question 4

What feature is necessary for nosocomial PUI

Answer 4

patient hospitalised >24h but no fever/incubating on admission

Question 5

What feature is necessary for immune deficient PUO

Answer 5

Neutrophil count low (<500)

Question 6

What feature is necessary for HIV associated PUO

Answer 6

HIV infection confirmed

Question 7

What three tests are necessary for investigating PUO

Answer 7

HIV, EBV, CMV

Question 8

What appears very quickly on EBV serology if patient si infected

Answer 8

VCA IgM

Also VCA IgG

Question 9

What appears later on in disease for EBV serology

Answer 9

EBNA-1 IgG

Question 10

which two conditions is very high ferritin associated with

Answer 10

Still’s disease

Macrophage activation syndrome

Question 11

What does Adult Still’s disease present as

Answer 11

inflammatory arthritis that features fevers, SALMON PINK RASH and joint pain