Virus, Hepatitis and Herpes (complete) Flashcards Preview

DMD 5245 > Virus, Hepatitis and Herpes (complete) > Flashcards

Flashcards in Virus, Hepatitis and Herpes (complete) Deck (51):
1

What is the classification for Herpesviridae

DNA
Icosahedral
Enveloped
Double Stranded (linear)

2

What are the strains of Herpes virus found in the oral cavity

HSV-1 (Herpes Simplex Virus)
HSV-2
EBV (Epstein-Barr virus)
CMV (Cytomegalo Virus)

3

Where are HSV-`1 infections usually found

in HSV infections above the waist

4

where are HSV-2 infections usually found

in HSV infections below the waist

5

Are Herpes infections often latent infections

yes

6

What are the 8 human herpes viruses

Herpes Simplex Virus-1 (HSV-1) HHV-1
Herpes Simplex Virus-2 (HSV-2) HHV-2
Varicella zoster Virus (VZV) HHV-3
Epstein-Barr Virus (EBV) HHV-4
Cytomegalo Virus (CMV) HHV-5
Herpes Simplex Virus-6 HHV-6
Herpes Simplex Virus-7 HHV-7
Herpes Simplex Virus-8 HHV-8

7

Where are HSV-1 and HSV-2 located in the human body

in the nerve ganglia

8

where is EBV found in the human body

in resting B cells

9

Where is CMV found in the human body

in the salivary glands??

10

Who is most susceptible to primary herpes

6 month to 6 year old children (adults are not very susceptible, except as STD)

11

What is caused by primary herpes

Gingivostomatitis

12

how many adults are Ab + to primary herpes

80%

13

how is primary herpes transmitted

saliva, kissing, close contact, fomites (toys)

14

how does primary herpes express on skin

excema, whilow, herpes gladitorum

15

how does primary herpes express on the cornea

keratojunctivitis

16

What type of herpes causes cold sores and fever blisters

HSV-1

17

Is ocular herpes primary herpes, or reactivation of latent herpes

reactivation of latent herpes

18

What happens to Herpes viridae after primary gingivostomatitis

the virus hangs out in the Trigeminal ganglion, then can be reactivated in the maxillary, mandibular and opthalmic branches of the nerve

19

What causes Herpes to reactivate

stress, excessive sunlight, fever, trauma, immunosuppression

20

What is the main difference between the infection steps of Herpesviridae and other viruses

Herpes viridae blocks the

21

What can secondary herpes virus cause

Blindness
Meningoencephalitis
Fulminant HSV
Transfer to fetus upon birth
whitlow
herpes gladitorum
pharyngitis, autoinoculation
loss of bladder control
pyschological trauma
interrupted personal relationship
stillbirths, spontaneous abortions

22

What does EBV cause

burkitt's lymphoma
hodgkins disease

23

how does an EBV infection differ from first to third world countries

in third world it is mostly asymptomatic
in the first world it is a delayed infection, infectious mononucleosis

24

How does EBV get transmitted

salivary droplets, oral-respiratory

25

where does the EBV replicate

in nasopharynx and salivary glands

26

What are the symptoms of an EBV? (mono)

Sore throat, malaise, fever-chills, headache, anorexia, profound fatigue

27

What is the most susceptible age group to EBV infection

18-22 years old

28

What do we do for EBV infections

we don't have a vaccine, and it is not sensitive to chemotherapy

29

What causes chicken pox

HHV-3 (VZV)

30

how does chicken pox relate to shingles

chicken pox is the is the primary infection HHV-3, shingles is the reactivation of that HHV-3 infection

31

What can CMV HHV-5 cause

in utero congenital infection, can cause mental retardation

32

Which two strands of HHV cause Roseola

HHV-6, and HHV-7

33

Which strand of HSV is associated with a kaposi sarcome

HHV-8

34

What is hepatitis

infection/inflammation of the liver

35

What is the classification of the hepadnaviridae (Hepatitis B)

DNA
Icosahedral
Enveloped
Double Stranded (circular) gapped

36

How is Hepadnaviridae transmitted

Parenteral inoculation (IDU, Tattoo needles, blood needles, dental instruments)
Sex
Transplacental
Oral (not common - requires 50x more virus)

37

what is the average incubation period for hepadnaviridae HEP B

75 days

38

What are the preicteric (before jaundice) symptoms of hepadnaviridae HEP B

anorexia, malaise, nausea, diarrhea, fever, abdominal discomfort

39

What are the icteric (jaundice) symptoms of hepadnaviridae HEP B

Dark urine, light colored stools, release of liver enzymes, possible cirrhosis, hepatocellular carcinoma, death

40

what are the two most likely outcome of hepadnaviridae HEP B infections

fairly quick recovery and death

41

How can hepadnaviridae HEP B infections be prevented

screen blood donors, screen units of blood, limited sex, no drug abuse, hygeine.
Vaccination

42

How is a hepadnaviridae HEP B infection treated

IFN - alpha and beta
lamivudine and famciclovir (DNA polymerase inhibitor)

43

What is the common name for Flaviviridae viruse

Hepatitus C virus

44

what is the classification for flaviviridae virus

RNA
Icosahedral
Enveloped
Single Stranded
Positive

45

what is used to treat HEP C

ritonavir, ombitasvir, dasabuvir, ribavirin

46

What is the virus that causes HEP A

Picornavirus

47

What is the classification of picornavirus

RNA
Icosahedral
Naked
Single Stranded
Positive

48

what are the main problematic symptoms of HEP A

jaundice, liver degeneration, and death

49

how is HEP A transmitted

the fecal-oral route (contaminated food and water
Shellfish
Drug abuse (needles)
Sexual Contact

50

how is HEP A prevented

hygeine, vaccination

51

who is the HEP A vaccine recommended for

those traveling to endemic countries
MSMs
IDUs
People who receive blood products
children and adolescents with historically high HEP a rates
NOT FOR PEOPLE WITH LIVER DISEASE