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Flashcards in viral respiratory viruses (complete) Deck (46):
1

What is the best idea of where influenza originated>

Geese and Ducks (migratory waterfowl)

2

What is the classification of orthomyxoviridae (influenza)

RNA, Helical, Enveloped, Single Strand, Negative, 8 Segments

3

What are the two important antigens on the influenza envelope

(H) = hemaglutanin
(N) = Neuroaminidase

4

What are the three types of Influenza virus

A, B, and C

5

What is the difference between A, B and C types of influenza virus

A - undergoes antigenic shift and drift
B - undergoes antigenic drift
C - relatively stable

6

Which two types of influenza virus infect humans A, B, or C

A and B

7

What does the H antigen do for Influenza virus

helps the virion attach, and lyse RBCs

8

What does the N antigen do for influenza virus

helps the virion separate from each other and infect

9

What does flu immunizations target

the H antigen

10

What does neuraminidase inhibitors target

the N antigen

11

What is an antigenic shift

when multiple strains of influenza infect the same cell, and mix up the 8 segments of their genome. This creates a brand new strain of influenza

12

What does an antigenic shift cause

a pandemic, the population has no immunity against the new strain

13

what is antigenic drift

a lot of base-pair mutations due to lack of repair mechanisms. As it happens more and more the genome becomes quite changed

14

What is a U age vs. death response

mostly young children and old die, not age groups between

15

What is a W age vs. death response

when young children, healthy adults, and the old die

16

What type of age vs. death response does influenza cause

W (the healthy young adults die because their immune system is so good and the flu kills by making it overactive)

17

What made the 2009 H1N1 flu pandemic so bad

you had antigenic shift with the familiar triple reassortment (swine, avian, human) and a new eurasian swine. This caused a new strain of flu for which the public didn't have immunity

18

What is the recommended 2016 trivalent flu vaccine

A/California/7/2009 (H1N1)
A/Switzerland/9715293/2013
B/Phuket/3073/2013

19

What is the recommended 2016 quadrivalent flu vaccine

A/California/7/2009 (H1N1)
A/Switzerland/9715293/2013
B/Phuket/3073/2013
B/Brisbane/60/2008

20

how effective are flu vaccines

about 60% effective

21

What is the peak month of flu activity

February

22

Which typically causes more cases of influenza type A or Type B

Type A

23

What are the 4 ways we attempt to control the flu

1. Neutralizing Antibody
2. M2 channel blockers
3. RNA replication
4. Neuraminidase inhibitors (NAIs)

24

What are the two common neuraminidase inhibitors (NAIs)

Tamiflu
Relenza

25

What are the common M2 channel blockers

Amantidine (Flu-A, needs to be early)
Rimantidine (fewer neurological side effects)

26

What is ribvarin

a broad spectrum antiviral for both influenza A and B

27

how effective are neuraminidase inhibitors

that is still in question

28

What are the main viruses in the paramyxoviridae family

parainfluenza
mumps
measles
Respiratory syncytial virus

29

What are the classifications of the parainfluenza virus

RNA
helical
enveloped
single stranded
negative

30

What is the most common manifestation of parainfluenza virus

croup (however it can be caused by influenza and RSV)

31

besides croup, what can parainfluenza cause

bronchiolitis
pneumonia
flu-like tracheobronchitis
Coryza-like illness

32

What do we use to fight parainfluenza

nothing, no chemotherapy or vaccine

33

What is the classification of RSV

RNA
Helical
Enveloped
Single Stranded
Negative
(part of the paramyxovirus family)

34

What does RSV cause

Children: croup, bronchiolitis, pneumonia potentially fatal
Older Children: Colds

35

What do we use to treat RSV

oxygen, humidifier, IV fluids
Ribvarin nasal inhalation in severe cases

36

What is the classification of the coronavirus

RNA
helical
enveloped
Single stranded
positive

37

What does the coronavirus cause

URT infection "bad sore throat" cold
SARS

38

what virus causes SARS

the coronavirus

39

What is the classification of adenoviruses

DNA
Icosahedral
naked
double stranded (linear)

40

What does the adenovirus cause

URT infections

41

what is our treatment for adenovirus infections

don't have one

42

Is there a vaccine against adenovirus

yes, but it is basically only given to military

43

What is the main viral cause of the common cold

rhinoviruses
(corona viruses are second)

44

What family does the rhinovirus belong to

picornaviridae

45

what is the classification of the picornavirdae

RNA
Icosahedral
Naked
single stranded
positive

46

What is the optimum temperature for the picornaviridae (rhinovirus)

33 C, the temp in the nose