WEEK 12: 12.1 Overview of Male Reproduction Flashcards

(44 cards)

1
Q

What are the 3 main functions of the male reproductive system?

A
  1. Production of sperm cells in the testes
  2. Sustaining and transfer of sperm cell to the female
  3. Production of male sex hormones (like testosterone) which is essential for the normal function of the reproductive system & the male body form.
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2
Q

What is a penis?

A

A specialised organ that deposits sperm into the female reproductive system

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3
Q

What is a primary sex organ?

A

they are called the gonads, where gametes and hormones are produced

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4
Q

What are the gonads in males? and what do they do?

A

the testes, they produce sperm cells and male sex hormones (androgens)

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5
Q

What is a secondary sex organ? give examples of them

A

structures that are essential in caring for and transporting sperm cells
they include ducts (urethra, ductus deferens) which transport sperm
accessory sex glands (seminal vesicles, prostate gland, bulbourethral glands), which sustain sperm and the penis

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6
Q

where is the scrotum located?

A

extends from the body behind the penis

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7
Q

what is the sturcture of the scrotum

A

it is sac-like
divided into 2 compartments
each contains a testis
contains dartos muscle (thin layer of smooth muscle) beneath scrotal skin
2 skeletal cremaster muscles that descend from the abdomen and cover each testis
rich blood & nerve supply

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8
Q

What are the function of the scrotum

A
  • support and protect the testes
  • help regulate the temperature of the testes, maintained at about 35 degrees for optimal sperm production & storage
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9
Q

What is the location of the testes?

A

paired testes are located within the scrotum

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10
Q

What is the structure of the testes?

A

oval shaped
divided into compartments called lobules
seminiferous tubule- long tube where sperm is produced
lined by serous membrane that reduces friction
deep CT capsule

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11
Q

What is the function of the testes?

A

sperm cells and male sex hormones are produced within the testes

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12
Q

Describe the 3 distinct regions of a mature sperm cell

A

Head: contains compact haploid nucleus with little cytoplasm.
Acrosome covers most of head, is filled with lysosomal enzymes that help sperm penetrate coats around oocyte
Mid-piece: connects the sperm head to the flagellum. contains mitochondria, which provide energy required for sperm tail motility.
Flagellum: whip-like tail that moves the sperm along

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13
Q

What are the seminal vesicles and what is their function?

A

paired, pouch-like glands attached to the ductus deferens .
they secrete 60-70% of the volume of semen
they neutralise the acidic environment of male urethra and female reproductive tract

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14
Q

What are prostate gland and what is their function

A

single donut shaped gland, inferior to bladder and surrounding urethra
secrete milky prostatic fluid, contributes 20-30% of volume of semen

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15
Q

What are the bulbourethral glands and what is their function?

A

They are paired pea-sized glands at the base of the penis, connected to the urethra
secrete alkaline mucus into the urethra prior to ejaculation that neutralises the urethra from urine and lubricates the penis

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16
Q

What is semen made up of?

A

seminal fluid from the accessory glands, combined with sperm from testes

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17
Q

Describe the 3 segments of the penis

A
  1. root at base of penis, internal within body
  2. body/shaft - elongated and composed of 3 cylindrical columns or erectile tissue: 2 large corpora cavernosa on sides of penis + 1 corpus spongiosum on underside of the penis, that surrounds urethra
  3. bulbous glans at end of penis, has a high concentration of nerve endings and normally covered by foreskin
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18
Q

What is the function of the penis

A

to deliver semen to the female during intercourse and transport urine out of the body

19
Q

Describe the mechanism of an erection

A
  1. sexual stimulation
  2. parasympathetic neurons release nitric oxide. this causes dilation of arteries leading to the penis, increasing blood flow into erectile tissues
  3. increasing pressure of arterial blood entering the vascular spaces of the erectile tissues compresses the veins of the penis, reducing flow of venous blood away from the penis
  4. blood accumulates in the vascular spaces within the erectile tissues of the penis
  5. following orgasm, sympathetic nerves contract the central artery of the penis and contract the smooth muscles around the erectile tissues, which expel blood out of the penis
20
Q

Where is testosterone produced and by what

A

it is produced by Leydig cells of the testes, and production increases during puberty, initiating spermatogenesis and activating characteristic physical changes.

21
Q

What are the functions of testosterone?

A

within the testes, to initiate and maintain spermatogenesis; low levels of testosterone can lead infertility
for development of male secondary sexual characteristics & maintaining sex drive (libido)

22
Q

Describe the negative feedback loop that regulates testosterone levels

A
  1. the hypothalamus initiates spermatogenesis by secreting GnRH, stimulates the anterior pituitary to secrete FSH and LH
  2. LH stimulates interstitial Leydig cells to secrete testosterone. FSH stimulates sustentacular cells to secrete androgen binding protein. ABP binds to testosterone and becomes more concentrated in the seminiferous tubule, ensuring testosterone levels remain high in testes
  3. high level stimulates spermatogenesis, which causes negative feedback on GnRH prod
  4. sertoli cells respond to rising sperm by secreting inhbin, inhibiting FSH secretion from anterior pituatary, negative feedback cycle
  5. circulating testosterone level stimulates sex drive (libido) and develop secondary sexual characteristics
23
Q

Where are testes located?

A

externally within the scrotum

24
Q

What do testes produce?

A

sperm & hormones

25
Why is the testes in an exposed location?
This reduces its temperature from 37 - 35 degrees
26
What could happen if core temp is bad?
abnormal spermatogenesis abnormal metabolism increased risk of testicular cancer
27
How is temperature maintained in the testes
1. location 2. cremaster muscle 3. dartos muscle
28
How does cremaster muscle maintain temperature?
when cold: it contracts to lift the testes closer to warm pelvis when hot: it relaxes to drop testes away from warm pelvis
29
How does dartos muscle maintain temperature?
when cold, it contracts to reduce surface area for heat loss (increased wrinkling) when warm, it expands to increase surface area & promote heat loss (reduced wrinkling)
30
How does the counter-current heat exchange work?
A network of veins wrap around the testicular artery to exchange heat from the artery to the vein
31
What is the main function of seminiferous tubules & what 2 cell types does it have
site of sperm production (spermatogenesis) 1. spermatogenic cells- become sperm 2. sertoli cells support cells developing into sperm
32
What exists between seminiferous tubules?
blood vessels leydig cells (which make testosterone)
33
What is the function of tight junctions in sertoli cells?
they stop diffusion in between cells
34
What is the blood testis barrier in the Sertoli cell, and what is its purpose?
The barrier is formed by tight junctions, prevents substances passing through hence isolates spermatogenic cells from blood. this is because the immune system recognizes sperm as foreign & barrier prevents a self-immune response
35
What are the 4 key functions of sertoli cell?
1. control release & movement of sperm cells 2. nourish sperm cells 3. prevent self-immune reaction 4. secrete inhibin to slow sperm production
36
What is spermatogenesis, where does it occur and how long does it take?
simple round cell ---> elaborate highly specialised cell begins in outermost layer of seminiferous tubules and proceeds to lumen takes 65-75 days
37
what 3 elements are involved in spermatogenesis?
1. mitotic proliferation- produce lots of cells 2. meiotic division- generate genetic diversity and half no of chromosomes 3. spermiogenesis - morphological change of cell
38
Describe the 4 key events associated with spermiogenesis?
1. development of acrosome 2. development of tail 3. condensation of nucleus 4. shedding of excess cytoplasm
39
What does the duct system compose of?
1. seminiferous tubules 2. rete testis (network of tubules that carry sperm from the testes to the efferent ducts) 3. efferent ducts (connect the rete testis to the epididymis) 4. epididymis 5. ductus vas deferens
40
what are the 5 functions of the epididymis
1. monitor and adjust composition of the fluid: produced by the seminiferous tubules - can absorb and secrete fluid 2. recycling centre for damaged sperm - resorb and breakdown cellular debris and damaged sperm 3. stores and protects sperm 4. concentrates sperm 5. site of functional maturation of sperm by secreting proteins that bind to sperm, stabilize sperm so it can withstand shearing forces during ejaculation & hence trigger flagellum to begin moving, increasing motility
41
What is the function of the ductus deferens?
thick layer of smooth muscle allows peristaltic contractions to propel sperm & fluid along duct. also stores sperm but mainly an ejaculatory duct
42
what are the 3 parts of the urethra
1. prostatic urethra - passes through prostate 2. membranous urethra 3. spongy urethra - passes through penis
43
what are the key components of seminal vesicles?
1. fructose (metabolised by sperm as sugar energy source) 2. prostaglandins (stimulate smooth muscle contractions in male reproductive tract & contribute to sperm motility and stability) 3. fibrinogen (coagulate semen after ejaculation to protect sperm from acidic environments)
44
What are the 3 key substances in the prostate gland?
1. citric acid - used for ATP 2. proteolytic enzymes - include fibrinolysin and prostate-specific antigen break down clotting proteins 3. seminalplasmin - antibiotic that prevents bacterial infections in male and female reproductive tracts