WEEK 8: 8.3 Salivary Glands, Oesophagus & Stomach Flashcards

(73 cards)

1
Q

What are different components of the mouth that play a role in ingestion?

A

hard palate
soft palate
uvula
palatine tonsil
tongue
duct of salivary gland
muscular lips

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2
Q

What are the 3 steps involved in mastication (chewing)

A
  1. grind and break up food into small sizes (increases surface area of food for salivary enzymes)
  2. mix with saliva
  3. stimulate taste buds (reflex increased in secretion)
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3
Q

What is saliva made up of?

A

water, electrolytes, protein, mucus
amylase (break polysaccharides into maltose)
lingual lipase (start fat digestion)
lysozyme (antibacterial)
bicarbonate buffer (neutralise acids and prevent dental decay)

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4
Q

What is the function of saliva?

A

breaks down food particles, washes particles away, acts as a solvent for taste

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5
Q

What is the usual type of secretion of saliva?

A

slow, continuous basal secretion

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6
Q

What two reflexes cause periods of increased secretion?

A

simple reflex
conditioned reflex

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7
Q

explain the difference between the simple and conditioned reflex?

A

in the simple reflex, pressure and chemoreceptors in the mouth activate the salivary center in the medulla, stimulating the autonomic nerves, which stimulate the salivary glands and increase salivation. however, in the conditioned reflex, the same process occurs but thinking of food, seeing food, smelling food activate the cerebral cortex activate the salivary centre in the medulla instead

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8
Q

Explain the voluntary oral stage of swallowing

A

the tongue pushes portion of food to be swallowed to back of oral cavity, by elevation and retraction against hard palate

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9
Q

explain the involuntary pharyngeal stage

A

breathing stops and airways are closed
soft palate and uvula lift to close nasopharynx
larynx elevates (causing epiglottis to be bent over), vocal cords close

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10
Q

explain the involuntary oesophageal stage

A

pharynx muscles contract - force bolus into oesophagus
while swallowing, larynx lifts, and upper oesophageal sphincter relaxes
sphincter closes as bolus passes
swallowing centre triggers peristalsis to push food down
lower sphincter relaces as food approaches

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11
Q

what are the two sphincters in the oesophagus and what are their functions?

A

pharyngoesophageal (upper): prevents excess air entering GIT
gastroesophageal (lower): keep out stomach contents to prevent heartburn

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12
Q

What is primary peristalsis

A

it is preceded by pharyngeal phase and controlled by the swallowing centre

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13
Q

What is secondary peristalsis?

A

occur without pharyngeal phase if oesophagus is distended eg. if food is stuck, and is characterised by stronger force

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14
Q

why does the oesophagus secrete mucus?

A

for lubrication and protection - to lessen damage from sharp sides of food

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15
Q

What structures make up the upper GIT?

A

oral cavity
pharynx
esophagus
stomach
small intestine:
duodenum
jejunum
ileum

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16
Q

what is the foregut supplied by?

A

celiac trunk

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17
Q

what is the foregut made up of?

A

esophagus
stomach
part of duodenum
pancreas
liver
gallbladder

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18
Q
A
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19
Q

Where does the esophagus travel through?

A

the neck, thoracic cavity and into the abdomen

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20
Q

what two layers of muscle of the muscularis externa does the esophagus consist of?

A

external longitudinal layer of muscle
internal circular layer of muscle
they allow efficient directional movement of food

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21
Q

which atrium of the heart does the esophagus travel behind?

A

left atrium.

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22
Q

at what level does the esophagus enter the diaphragm at?

A

level T10

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23
Q

what are the two types of muscle that the esophagus consists of?

A

striated and smooth muscle

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24
Q

What kind of peritoneal is the stomach

A

intraperitoneal

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25
what are the different regions of the stomach?
cardia, fundus, body, pylorus
26
what is the function of the stomach?
storage, mixing, denaturation, degradation
27
Why does the stomach produce intrinsic factor?
to help resorb vitamin B12 in the ileum
28
What else does the body of the stomach produce?
H+, Cl- pepsinogen (precursor of pepsin) mucus containing HCO3- (balances pH)
29
What does the cardia, antrum and pylorus produce?
mucus containing HCO3-
30
what are the differences in glandular mucosa between the body and the stomach and the antrum?
in the corpus, there are oxyntic glands, focused on acid and enzyme secretion for digestion in the pyloric region, the glands are focused on endocrine regulation
31
what is the site of most pronounced motility in the stomach?
the antrum, it is important for mixing due to its muscularity
32
what sphincter of the stomach is a barrier to the small intestine?
pyloric sphincter
33
what are the functions of the stomach?
to store food secrete HCl and enzymes to begin protein digestion create chyme from mixing food with secretions
34
how does the stomach increase its volume above its resting capacity of 50mL to 1L?
receptive relaxation of the stomach, with its folds (gastric ruggae) getting smaller and flattening
35
what happens if over 1 litre is consumed and the stomach becomes over-distended?
intragastric pressure increases and rugae cannot account for this increase in pressure anymore, hence causing discomfort
36
What generates slow electrical waves in the stomach?
Interstitial cell of cajal
37
How do slow wave potentials sweep from the fundus to the pyloric sphincter?
via gap junctions
38
What happens when slow wave potential reaches threshold in smooth muscle cells?
action potentials are triggered, causing contraction/peristalsis and hence allowing mixing to occur
39
why is there stronger contractions in the antrum ?
because there are stronger contractions hence strong mixing
40
why are there weaker contractions at the fundus?
because the muscle there is thinner
41
why is only a small amount of chyme released into the duodenum with each contraction of the pyloric sphincter?
so the small intestine can perform its function efficiently- it is a slow digestive process
42
Why is the pyloric sphincter closed constantly ?
So chyme hits closed pyloric sphincter and tumbles back into the antrum to continue mixing and digesting
43
What aspect of antral peristaltic contractions control mixing and emptying?
intensity of it
44
what in the stomach is influenced by increased antral motility?
volume of chyme and fluidity
45
how does increased stretch increase gastric motility?
influences the nervous system by increasing rapid firing of action potentials, which trigger the vagus nerve and increase the hormone gastrin, which thus stimulates motility
46
What inhibits gastric motility and emptying in the duodenum?
Fat (slowly digested) Acid (chyme must be neutralised + irritates mucosa) Hypertonicity (amino acids/glucose draws water from plasma to reach isotonicity) Distension (too much chyme, excess vol)
47
How does the duodenum affect gastric motility?
inhibitory Neural and hormonal responses upon stomach
48
What neural and hormonal responses specifically?
the enterogastric reflex enterogastrones (secretin and CCK) which inhibit antral contractions
49
What external factors can influence motility?
emotion, fear, pain
50
How can stimulation of the sympathetic NS due to a fear response alter motility?
it decreases motility
51
What is emesis?
expulsion of gastric content through the mouth
52
What are causes of emesis?
chemical factors psychogenic increased intracranial pressure stimulation at back of throat irritation/distension of stomach/duodenum motion sickness
53
where are secretory cells in the stomach located?
in mucosa in-foldings
54
what type of secretions can these mucosal in-foldings be?
exocrine, paracrine or endocrine
55
Are gastric glands located above or beneath gastric pits?
beneath
56
what are the two areas of gastric mucosa?
pyloric gland area (antrum) oxyntic mucosa (fundus and body)
57
alkaline mucus is secreted from where?
surface epithelial cells
58
exocrine secretions exit from gastric pits onto?
luminal surface
59
what is primarily secreted in the oxyntic mucosa?
acid
60
what secreting cells reside in the oxyntic mucosa?
mucous cells parietal cells chief cells enterochromaffin-like cells
61
what secreting cells reside in the pyloric gland area?
G cells (gastrin) D cells (somatostatin)
62
What product do mucous cells, chief cells and parietal cells secrete?
alkaline mucus pepsinogen hydrochloric acid + IF
63
what is the function of mucous cells?
protect mucosa against mechanical pepsin and acid injury
64
what is the function of chief cells?
when activated by gastrin, begins protein digestion
65
what is the function of parietal cells?
when activated by ACh and gastrin, activates pepsinogen, breaks down connective tissue, denatures proteins, kills microorganisms + facilitates absorption of vitamin B12
66
What is the function of mucus in the stomach?
1. lubricating (no mechanical injury) 2. inhibits pepsin (no self-digestion) 3. alkaline secretion (bicarbonate neutralizes acid) to combat high acidity in lumen due to HCl hence preventing acid injury
67
where is pepsinogen synthesised and packaged
by ER and Golgi complex in chief cells
68
where is pepsinogen exocytosed from
storage vesicles
69
what is pepsinogen activated to pepsin by?
HCl via autocatalytic activation
70
how does pepsinogen initiate protein digestion?
by cleaving peptide bonds
71
Is hydrocholric acid a digestive enzyme?
No, but it aids digestion
72
What cell is HCl released from?
parietal cells
73
What does HCl do to create optimal pH for activity in the stomach?
it activates pepsinogen to the active pepsin denatures proteins antibacterial (kills microorganisms) breaks down connective tissue and muscle fibres