WEEK 4- Fibro pt 2

Question 1

anterolateral system carries what type of info

Answer 1

pain temp
crude touch pressure

Question 2

lateral spino carries what modality

Answer 2

pain temp

Question 3

pain and temp are carries in what type of axons

Answer 3

a delta
c

Question 4

true or false c fibers are faster than a delta

Answer 4

false, c is unmyelenated

Question 5

‘An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage’. described what

Answer 5

PAIN

Question 6

is pain subjective

Answer 6

yes

Question 7

true or false, pain is only expressed by sensory feelings

Answer 7

FALSE
whole bunch of networks

Question 8

pain and temperature are sensed by what type of cutaneous receptor

Answer 8

free nerve endings

Question 9

what general category of receptors does pain get felt by

Answer 9

NOCICEPTORS

Question 10

true or false nociceptors have large diamter axons

Answer 10

false

Question 11

true or false all nociceptors are myelnated

Answer 11

false, c fibers are not

Question 12

true or false nocicpetors conduct fact signals

Answer 12

FALSE

Question 13

which provides more localized location for stimulus touch or pain

Answer 13

touch

Question 14

Transient receptor potential (TRP) can sense what kind of stimuli

Answer 14

reacts to heat and capsacian

Question 15

what is capsacian

Answer 15

pepper = hot

Question 16

what is a TRP

Answer 16

specific receptor on the periphery that senses heat and capsacian

Question 17

does trp only sense heat

Answer 17

no capsacian also

Question 18

true or false there exisst Specific receptors for a variety of stimuli

Answer 18

true
chemical, thermal, or mechanical - under

Question 19

which fibers do we find the receptors in

Answer 19

a delta
c

Question 20

true or false at rest the pore of teh receptor in the neuron for pain is closed

Answer 20

true

Question 21

true or false we have different trp channels

Answer 21

true

Question 22

where are trp channels located

Answer 22

DRG

Question 23

true or false TRP are Ion channels located on the plasma membrane

Answer 23

true

Question 24

what do TRP receptors mediate

Answer 24

pain, hotness, warmth or coldness, different kinds of tastes, and pressure.

Question 25

for example if we have a trp receptor for temperature , would above 45 degrees be considered painful?

Answer 25

yes = starts to be detected as nociceptiron

Question 26

Thermal (Aδ-I fibers) –

Answer 26

extreme temperature > 45°C or < 17°C

Question 27

Mechanical (Aδ-II fibers)

Answer 27

– intense pressure applied to the skin

Question 28

Polymodal (C-fibers) –

Answer 28

high-intensity mechanical, thermal or chemical

Question 29

what can create pain

Answer 29

capsasium cream extremely cold water needles

Question 30

Thermoreceptive afferents :

Answer 30

discharge with non-painful and non- damaging warming of the skin

Question 31

n Nociceptors only begin to discharge

Answer 31

with skin temperatures that cause tissue damage

Question 32

true or false nociceptors can sense pain at higher temperatures

Answer 32

true

Question 33

do thermoreceptors discriminate between painful temperature and normal temperature

Answer 33

yes1

Question 34

how many nociceptor mechanisms do we have (fibers)

Answer 34

2

Question 35

sharp initial pain is asscoiated with what fiber

Answer 35

a delta

Question 36

dull long lasting second pain is associate dwith which fiber

Answer 36

c

Question 37

what othe rmodalities besides pain and temp doe sthe anterolasteral system account for

Answer 37

n Non-discriminative touch (in the absence of dorsal columns) n Innocuous warm & cold temperature sensations n Histamine – hitch n Slow mechanical sensation – sensual touch n Sensors of lactic acid released during muscle contraction

Question 38

c fibers synapse have input in what layers of dorsal horn

Answer 38

1 and 2

Question 39

a delta fibers have input in what layers of dorsal horn

Answer 39

1 and 5

Question 40

true or false Neurons in layer V receive ONLY nociceptive inpiuts

Answer 40

false non nociceptive also

Question 41

where do 2nd neurons cross teh midline

Answer 41

AWC

Question 42

what is referred pain

Answer 42

Pain perceived at a location other than the site of the painful stimulus

Question 43

what is the theory that helps explain referred pain

Answer 43

Convergence of nociceptors onto the same neurons in the dorsal horn = visceral disorders felt as cutaneous pain.

Question 44

UNDERSTAND ANTEROLATERAL PATHWAY

Answer 44

!

Question 45

know lesion type questions

Answer 45

is it ipsilateral or contralateral

Question 46

is pain processed by a single cortical region?

Answer 46

no Pain in processed by diverse and distributed networks / significance unclear

Question 47

what is an example of peripheral sensitixation

Answer 47

hyperlagesia

Question 48

what is hyper algesia

Answer 48

noxious stimulus that causes MORE pain than it should

Question 49

talk about the chemistry of sensitixation

Answer 49

1) Nociceptors are depolarized by chemicals released in the environment around the terminal 2) Nociceptors release substances that contribute to inflammatory processes 3) Some chemicals sensitize the terminals of nociceptors so as to reduce their threshold 4) After sensitization of “pain fibres”, normally non- painful stimuli can cause pain Protect injured area + promote healing & guard against infection (↑ blood flow + white cells migration)

Question 50

what is an example of central sensitization

Answer 50

allodynia

Question 51

what is allodynia

Answer 51

painful reaction to non noxious stimuli Pain not felt constantly (sensation = light stroking of sunburned skin)

Question 52

wh

Question 53

at are two pain modulation tecniques

Answer 53

gate theory endogenous opiods

Question 54

what are examples of exogenous ways to relive pain

Answer 54

opioids cannabis

Question 55

is acute pain useful

Answer 55

yes

Question 56

is chronic pain useful

Answer 56

she never answered this lol