Wk3 Female Repro Drugs Flashcards Preview

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Flashcards in Wk3 Female Repro Drugs Deck (20):
1

Drug used to stimulate FSH secretion by blocking estrogen receptors:

clomiphine citrate

2

MOA of clomiphine citrate:

estrogen receptor antagonist

block negative feedback

***increasing GnRH, LH, FSH release

3

menotropin

FSH/LH analog

4

urofolitropin

FSH/LH analog

5

used to stimulate induction of ovulation by acting like LH

hCG

6

Synthetic GnRH analog (agonist)

Leuprolide

7

What happens INITIALLY if a NONpulsatile dose of Leuprolide is administered?

transient RISE in FSH/LH

followed by decrease

8

What happens with pulsatile administration of Leuprolide?

increases FSH/LH --> follicle development

9

GnRH ANtagonists:

ganiRELIX

cetroRELIX

10

Pure estrogen antagonist in all tissue

Fulvestrant

11

NONsteroidal

Reversible

Aromatase inhibitors

anasTROZOLE

leTROZOLE

12

Steroidal

NONreversible

Aromatase inhibitor

Exemestane

13

Main idea with aromatase inhibitors:

prevent estrogen production

used in estrogen+ cancers

14

Progestin analog for contraception

Medroxyprogesterone acetate

15

estrane analog for contraception

progesterone receptor agonist

Norethindrone

16

gonane analog for contraception

progesterone receptor agonist

Levonorgestrel

17

Progesterone agonist used as emergency contraceptive

cannot terminate pregnancy

Levonogestrel (Plan B)

18

Selective Progesterone Receptor antagonist used to prevent ovulation (low dose) or terminate early pregnancy (high doses with misoprostol)

Mifepristone

19

PGE1 analog

misoprostol

20

Progesterone ANtagonist for emergency contraception

prevents or delays ovulation

Ulipristal acetate