Flashcards in Wk3 Anti-neoplastic Hormones Deck (17)
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1
Goserelin
GnRH receptor agonist
inhibits FSH/LH secretion AFTER initial spike
combine with steroid inhibitor
2
Degarelix
GnRH receptor ANtagonist
inhibits FSH/LH release
3
Finasteride
5-a-reductase inhibitor
inhibits conversion of testosterone --> DHT
4
Abiraterone acetate
17-a-hydroxylase inhibitor
prevent testosterone synthesis
5
Bicalutamide
testosterone receptor antagonist
6
Flutamide
testosterone receptor antagonist
7
Oxandralone
DHT receptor agonist
**not used for prostate cancer -- would make it worse
8
Typical tx for prostate CA:
GnRH agonist + testosterone receptor blocker
goserelin or leuprolide + bicalutamide
9
Leuprolide
GnRH receptor agonist
10
typical Breast CA regimen
standard chemo --> GrRH modulator --> aromatse inhibitor --> estrogen receptor modulator
11
Anastrazole
aromatase inhibitor
12
Exemestane
irreversible aromatase inhibitor
13
Tamoxifen
estrogen receptor modulator
antagonizes receptor in breast
**stimulate it in ovary --> inc. risk of ovarian CA
14
Raloxifene
Estrogen antagonist in breast
and uterus
15
Fulvestrant
Universal estrogen receptor blocker
16
Positive side effects of tamoxifen and raloxifene
stimulate estrogen receptors in bone combating osteoporosis
17
