Wk3 Anti-neoplastic Hormones Flashcards Preview

Endo/Repro > Wk3 Anti-neoplastic Hormones > Flashcards

Flashcards in Wk3 Anti-neoplastic Hormones Deck (17):
1

Goserelin

GnRH receptor agonist

inhibits FSH/LH secretion AFTER initial spike

combine with steroid inhibitor

2

Degarelix

GnRH receptor ANtagonist

inhibits FSH/LH release

3

Finasteride

5-a-reductase inhibitor

inhibits conversion of testosterone --> DHT

4

Abiraterone acetate

17-a-hydroxylase inhibitor

prevent testosterone synthesis

5

Bicalutamide

testosterone receptor antagonist

6

Flutamide

testosterone receptor antagonist

7

Oxandralone

DHT receptor agonist

**not used for prostate cancer -- would make it worse

8

Typical tx for prostate CA:

GnRH agonist + testosterone receptor blocker

goserelin or leuprolide + bicalutamide

9

Leuprolide

GnRH receptor agonist

10

typical Breast CA regimen

standard chemo --> GrRH modulator --> aromatse inhibitor --> estrogen receptor modulator

11

Anastrazole

aromatase inhibitor

12

Exemestane

irreversible aromatase inhibitor

13

Tamoxifen

estrogen receptor modulator

antagonizes receptor in breast

**stimulate it in ovary --> inc. risk of ovarian CA

14

Raloxifene

Estrogen antagonist in breast

and uterus

15

Fulvestrant

Universal estrogen receptor blocker

16

Positive side effects of tamoxifen and raloxifene

stimulate estrogen receptors in bone combating osteoporosis

17

Why is synergism good?

lower doses of multiple drugs reduces toxicity