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Flashcards in Wk3 STDs Deck (47):
1

Urethritis in male (inflammatory, exudative infection

Ddx:

Neiseria gonorrhoeae

Chlamydia trachomatis

2

Cervicitis

Ddx:

Chlamydia trachomatis

3

Vaginitis Ddx:

T. vaginalis

C. albicans

4

Vaginosis Ddx:

Gardnerella

5

HPV

genome?

capsid?

envelopment?

dsDNA group I

circular genome

Icosahedral

Nonenveloped

6

Cancer causing factor in HPV:

episome E6 --> decreased p53 --> accumulation of mutations

episome E7 --> knocks out Rb

7

typically purulent discharge in male:

Neisseria gonorrhea

8

typically clear discharge in male:

Chlamydia trachomatis

9

N. gonorrhoeae virulence factors

pilli -- prevents phagocytosis

endotoxin

capsule

IgA protease

10

Thayer Martin media

N. gonorrhoeae

11

Glucose oxidizer

N. gonorrhoeae

12

G -

dipplococci

oxidase +

N. gonorrhoeae

13

Tx for N. gonorrhoeae

ceftriaxone

(+ doxy for probable concurrent Chlamydia)

14

Prophylaxis in neonates from N. gonorrhoeae mother

erythromycin eye drops

15

N. gonorrhoeae

gram ?

Gram -

16

N. gonorrhoea

Oxidase ?

oxidase +

17

Complications of untreated N. gonorrhoeae:

PID

ectopic pregnancy

sterility

Fitz-Hugh-Curtis syndrome

18

LIver infx from N. gonorrhoeae

Fitz Hugh Curtis synd

19

most common cause of septic arthritis in sexually active people

N. gonorrhoeae

20

Prevents lasting immunity after N. gonorrhoeae infx:

antigenic variation

21

Painful penile ulcers in men:

HSV -- small blisters

Chanchroid (Haemohylus ducryei) -- ugly red

22

Syphilis real name:

T. pallidum

23

Painless ulcers

T. pallidum

24

Alpha herpes viruses (HSV 1/2)

genome?

capsid?

envelopment?

dsDNA group I

LInear genome

Icosahedral

Enveloped

25

Immune control of HSV

cell mediated

26

Tzank smear with giant multinucleated cells:

HSV

27

Tzank smear without multinucleated giant cells:

H. ducryei --- aka Chanchroid

28

Cowdry bodies type A

HSV

29

Tx for HSV

acyclovir

30

MOA for acyclovir

activated by viral thymidine kinase

chain terminator

selective toxicity for active viral infx

31

3 likely causes of vaginal (NOT urethral) discharge

1. Gardnerella -- white/grey, SMELLY

2. Candida albicans -- itchy, white, small clumps

3. Trichomonas vaginalis -- itchy, yellowish, large amount

32

fishy odor

bacterial vaginosis

Gardnerella

33

clue cells

bacterial vaginosis

34

flagellated protozoan

Trichomonas

35

Tx for trichomoniasis

metronidazole

36

Most common cause of vaginitis

C. albicans

"yeast infection"

37

Indication that C. albicans is growing rapidly

pseudohyphae

38

Mech of disease for C. albicans

opportunistic

ie. post abx

39

1. What cell types does HIV infect, and why does this have such an impact on the patient’s immune response?

2. How does the virus replicate?

3. To what other opportunistic infections is this woman susceptible?

4. What are the risk factors for infection?

5. How can the infection be treated?

Can infect T cells and macrophages. Need CD4, CXCR4, or CCR5.

Reverse transcription.

Many, list some…

Unprotected sexual intercourse, contaminated blood.

HAART. NNRTI + 2 NRTI or PI + 2 NRTI.

40

rash on palms and soles of feet

T. pallidum

41

hard chancre at site of pathogen entry

T. pallidum

42

systemic invasion

diffuse rash

hair falls out

3 weeks - 6 mo after infx

Secondary syphilis

43

latent period up to 20 years

tertiary syphilis

44

gummas

tertiary syphillis

45

gram -

spirochete

T. pallidum

46

Host antigen that has antibodies indicative of syphilis

cardiolipin

47

Tx for syphilis

Penicillin G