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Flashcards in Wk3 STDs Deck (47)
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1

Urethritis in male (inflammatory, exudative infection

Ddx:

Neiseria gonorrhoeae

Chlamydia trachomatis

2

Cervicitis

Ddx:

Chlamydia trachomatis

3

Vaginitis Ddx:

T. vaginalis

C. albicans

4

Vaginosis Ddx:

Gardnerella

5

HPV

genome?

capsid?

envelopment?

dsDNA group I

circular genome

Icosahedral

Nonenveloped

6

Cancer causing factor in HPV:

episome E6 --> decreased p53 --> accumulation of mutations

episome E7 --> knocks out Rb

7

typically purulent discharge in male:

Neisseria gonorrhea

8

typically clear discharge in male:

Chlamydia trachomatis

9

N. gonorrhoeae virulence factors

pilli -- prevents phagocytosis

endotoxin

capsule

IgA protease

10

Thayer Martin media

N. gonorrhoeae

11

Glucose oxidizer

N. gonorrhoeae

12

G -

dipplococci

oxidase +

N. gonorrhoeae

13

Tx for N. gonorrhoeae

ceftriaxone

(+ doxy for probable concurrent Chlamydia)

14

Prophylaxis in neonates from N. gonorrhoeae mother

erythromycin eye drops

15

N. gonorrhoeae

gram ?

Gram -

16

N. gonorrhoea

Oxidase ?

oxidase +

17

Complications of untreated N. gonorrhoeae:

PID

ectopic pregnancy

sterility

Fitz-Hugh-Curtis syndrome

18

LIver infx from N. gonorrhoeae

Fitz Hugh Curtis synd

19

most common cause of septic arthritis in sexually active people

N. gonorrhoeae

20

Prevents lasting immunity after N. gonorrhoeae infx:

antigenic variation

21

Painful penile ulcers in men:

HSV -- small blisters

Chanchroid (Haemohylus ducryei) -- ugly red

22

Syphilis real name:

T. pallidum

23

Painless ulcers

T. pallidum

24

Alpha herpes viruses (HSV 1/2)

genome?

capsid?

envelopment?

dsDNA group I

LInear genome

Icosahedral

Enveloped

25

Immune control of HSV

cell mediated

26

Tzank smear with giant multinucleated cells:

HSV

27

Tzank smear without multinucleated giant cells:

H. ducryei --- aka Chanchroid

28

Cowdry bodies type A

HSV

29

Tx for HSV

acyclovir

30

MOA for acyclovir

activated by viral thymidine kinase

chain terminator

selective toxicity for active viral infx