Wk1 Pineal, Thyroid, Parathyroid Histo Flashcards Preview

Endo/Repro > Wk1 Pineal, Thyroid, Parathyroid Histo > Flashcards

Flashcards in Wk1 Pineal, Thyroid, Parathyroid Histo Deck (19):
1

95% of the cells making up pineal gland:

Pinealocytes

2

What do pinealocytes do?

make melatonin at night

3

What is "brain sand" and what is its significance?

Ca and P buildup in pineal gland

radiological marker for small pineal gland

4

Nerve supply and NT released on pinealocytes:

superior cervical ganglion SNS fibers

epi

5

Melatonin effects on hypothalamus:

suppress gonadotropins (FSH, LH)

**pineal tumors cause precocious puberty

**possibly contributes to seasonal affective disorder

6

Two thyroid cell types:

follicular -- surround colloid

parafollicular (C-cells)

7

Thyroid hormone precursor found in colloid:

thyroglobulin

8

Where are thyroid hormones synthesized?

follicular cells

9

Slides 23-24

active vs resting follicular cells

10

Role of parafollicular cells?

synthesize calcitonin

11

3 roles of calcitonin:

1. lowers blood Ca by decreasing bone resorption

2. decreases osteoclast motility and number

3. promotes Ca and PO4 excretion by kidney

12

Where does iodination of thyroglobulin occur?

colloid

13

Nice summary on slide...

36-37

14

Embryological origin of C-cells:

pharyngeal endoderm

15

Embryological origin of parathyroid glands:

pharyngeal endoderm

16

3 cell types in parathyroid gland:

1. Chief (principal) cells

2. Oxyphils

3. Fat cells

17

Cells that produce parathyroid hormone (PTH):

Chief

18

Role of PTH:

Ca regulation

1. stimulates osteoBlasts which in turn produce RANKL to stimulate osteoClasts (no PTH receptor)

--> bone resorption --> increased blood Ca

19

Larger pink cells with small dark nuclei in parathyroid:

Oxyphhils