Wk3 Male Repro Phys Flashcards Preview

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Flashcards in Wk3 Male Repro Phys Deck (34)
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1
Q

Duration of a full cycle of spermatogenesis; “spermatogenic wave”:

A

64 days

2
Q

Inhibin inhibits?

A

anterior pituitary

FSH and LH

3
Q

Testosterone inhibits:

A

Hypothalamus AND Anterior pituitary

FSH/LH and GnRH

4
Q

LH acts on _______ cells.

A

Leydig

5
Q

FSH acts on _______ cells.

A

Sertoli

6
Q

Inhibin comes from _________ cells.

A

Sertoli

7
Q

Numerical relationship between sperm production and Sertoli cell number:

A

linear

8
Q

Numerical relationship between sperm production and Leydig cell number:

Why?

A

Linear

Testosterone helps stimulate Sertoli cells

9
Q

What would decreased testosterone levels do to GrRH?

A

increase

**less negative feedback

10
Q

Physical musculoskeletal effects of low testosterone:

A

increased abdominal fat

decreased muscle mass

11
Q

Finasteride

A

5-a-reductase inhibitor

Tx for: baldness, prostate CA

12
Q

What does 5-a-reductase do?

A

converts testosterone to DHT (more potent form)

13
Q

Testosterone targets:

A

Muscle

Seminal Vesicle

Epidydimis

Bone

14
Q

8 mg of daily testosterone in males produced in which two places?

A

Leydig cells (Testes) — 95%

adrenals — 5%

15
Q

Androgen receptor location and site of action:

A

cytoplasm — binding of androgens

nuclear transcription factors

16
Q

Anabolic effects of androgens (3):

A
  1. muscle building
  2. bone growth – closure of epiphysis
  3. Na/H2O retention
17
Q

Read slide….

A

20

18
Q

Testosterone analog

hormone replacement

hepatotoxic

A

Methyl testosterone

19
Q

DHT derivative

anabolic steroid

A

Oxandrolone

20
Q

What happens to gonads with exogenous testosterone use:

A

shrink

**inhibits hypothalamic pituitary axis –> no stimulation of androgen receptors

21
Q

Read slide…

A

28

22
Q

Non-steroidal

Pure steroid receptor antagonists

A

Flutamide

Bicalutamide

23
Q

Difference between “pulsatile” and “continuous” exposure to GnRH analogs:

A

“pulsatile” is stimulatory

“continuous” is inhibitory

24
Q

GnRH analog (recombinant human form)

pulsatile for 3-6 mo for male infertility

A

Gonadorelin

25
Q

GnRH analog (synthetic)

continuous for chemical castration in prostate CA

A

Leuprolide

**initial surge in Testosterone due to hypersecretion of LH and FSH

followed by suppression (~10 days after) due to desensitization of GnRH receptors

26
Q

GnRH recepto blocker

prostate CA

BPH

A

Degarelix

27
Q

GnRH receptor blocker

blocks premature LH surge in females

A

Ganirelix

Cetrorelix

28
Q

Major difference between GnRH agonists and antagonists

A

antagonists don’t have initial hypersecretory phase

29
Q

5-a-reductase inhibitor

BPH

prostate CA

baldness

A

Finasteride

30
Q

NT for parasympathetic nerve responsible for erection

A

NO

31
Q

NO second messenger?

A

Guanalyl cyclase –> increases intracellular cGMP

cGMP promotes arteriole dilation

32
Q

What degrades cGMP in vascular SM to end an erection?

A

Phosphodiesterase 5

33
Q

Phosphodiesterase 5 inhibitor to facilitate erection:

A

Sildenafil — Viagra

Tadalafil — cialis — longer duration

34
Q

What not to use with PDE-5 blockers?

A

alpha-blocker!!!

double whammy on vasodilation –> hypotension