1. wk 3 Reversible cellular changes accumulations (f) Flashcards Preview

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Flashcards in 1. wk 3 Reversible cellular changes accumulations (f) Deck (25):
1

(3) categories of intracelluar accumulations that can occur

1. endogenous sub.- produced at a normal rate, but metabolism rate is inadequate

2. lack of enzyme

3. accum. of an abnormal exogenous sub.

2

accum of fat in the liver is usually due to a normal endogenous sub produced, but the _______ is inadequate

rate of metabolism

3

c.c. Lysosomal storage dx (L.S.D): is caused by a lack of ______ needed for metab.

enzyme

4

c.c _____: condition where there was an inability to degrade phagocytosed particles

carbon pigment accumulation

5

accum of triglycerides in the cytoplasm during steatosis appear as _______

vacuoles

6

fatty changes are most often seen in what organ?

What is the name of this cc

liver

steatosis

7

(4) secondary caused to increas. syn of triglycerides in the liver

1. increased fat uptake (obesity)
2. excess lipolysis (diabetes, alcohol, corticosteroids)
3. decreased oxidation of FA (alcohl, hypoxia, hepatotoxin
4. increased syn of FA (alcohol)

8

(3) conditions that occur bc of alcohol abuse

1. enhance lipolysis
2. increas. FT synthesis
3. decreas. FA oxidation

9

If the liver has a yellowish hue, this indicates a _______

fatty change

10

c.c. ______: yellow bands alternating with normal red brown uninvolved bands with heart steatonis

tabby cat

11

c.c.________: cholesterol accum. in smooth M cells and macrophages

atherosclerosis

12

c.c._____: cholesterol accum in subepithelial CT

hyperlipidemia

13

C.C._____: yellow plaque that forms on the skin

xanthomas

(hyperlipidemia)

14

cc.____: yellowing of the eyes

xanthelasma

(hyperlipidemia)

15

c.c_____: accum of immunoglobins in cytoplasm of malignant plasma cells (Russell bodies)

multiple myeloma

16

c.c. russell bodies are rounded eosinophilic bodies from ______

multiple myeloma

17

c.c___ accum of carbon part. of coal dust or air polution

anthracosis

18

_____ is the wear and tear lipochrome pigment

lipofuscin

19

lipofuscin is caused by degraded _________

membranes of cytoplasmic organelles

20

melanin is formed when tyrosinase convertes _____ into _____

tyrosine into dihydroxyphenylalanine

21

c.c.______: excess iron causes accum of iron

hemosiderin

22

(4) causes of hemosiderin

1. incre. absorption of iron
2.impaired iron utilization
3. anemia
4. blood transfusions

23

_____ is derived from the non iron portion of hempglobin

bilirubin

(jaundice)

24

jaundice results from (3)

1. increase production due to increase destruction of RBC
2. decrease excretion
3. obstruction of bile flow

25

____ is yellowing of the sclera of the eye

icterus