Dani - ch 6 Flashcards Preview

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Flashcards in Dani - ch 6 Deck (28):
1

chronic inflammation
- follows ___ inflammation
- ____ attacks of acute inflammation
- begins ____

acute
repeated
insidiously

2

immune response of chronic inflammation
- presence of 3 cells

macrophage
lymphocyte
plasma cells

3

phagocytosis of chronic inflammation is doen by ____ activated by gamma interferon, Ig, and complement

macrophages

4

repair of damage tissue from chronic inflammation done by new ___ ___ and proliferation of ___ and ___

blood vessels
fibroblasts
fbrosis

5

differences from acute inflammation
- ___ onset
- ___ course
- vasodilation: mild (no ___ or ___)
- scanty exudate: no ____
- chronic inflammatory cells: __ and ___ lymphocytes, plasma cells and ____

insidious
progressive
redness;hotness
edema
B and T; macrophages

6

immune activation of monocytes to phagocytize

gamma interferon

7

non-immune activation of monocytes to phagocytize

bacterial endotoxin

8

morphology of monocytes in chronic inflammation
- ___ size of cells
- more ___ metabolism
- more ____ enzymes

larger
active
lysosomal

9

monocytes are ___ cells, kills bacteria by ___ dependent and ____ mechanisms

scavenger
oxygen
independent

10

___ cells: produce antibodies against foreign antigens or modified tissue antigen

plasma

11

___: mobilized in both antibody ad cell mediated immune reactions

lymphocytes

12

___ lymphocytes are activated in antibody immune reactions and ___ lymphocytes are activated in cell mediated immune reactions

B
T

13

____: immune reaction mediated by IgE and parasitic infection

eosinophils

14

___: may persist in chronic inflammation

neutrophils

15

granulomatous chronic inflammation: presence of ____

granuloma

16

2 types of granulomatous chronic inflammation cells

epitheloid
giant

17

epitheloid cells
- essential for ___
- are ____ macrophages
- abundant __ ___ cytoplasm
- elongated ____ nucleus

diagnosis
modified
pale pink
vesicular

18

giant cells
- ____, 40-50
- coalescence of ___
- __ or more nuclei
- ___ and foreign body ___ cell

large
macrophages
20
langhan's
giant

19

granulomatous chronic inflammation
- central ___
- peripheral rim of 4 cells

necrosis
lymphocytes
plasma cells
neutrophils
collagen fibers

20

granulomatous chronic inflammation occurs in 2 types of diseases

infections
chemical

21

non-granulomatous chronic inflammation
- ___ inflammatory cells are scattered ___ throughout the tissue

chronic
throughout

22

___ and ___ are common in non-granulomatous chronic inflammation

necrosis
fibrosis

23

systemic manifestation of inflammation:
- heat regulating center in ____ --> ___ stimulation --> ___ of skin vessels --> ___ heat loss --> ____

hypothalamus
sympathetic
vasoconstriction
decreased
fever

24

fever is caused by liberation of pyrogens ___ and ___

IL-1 and TNF

25

heat regulating center in hypothalamus act directly or by local production of ____

prostaglandins

26

systemic manifestation of inflammation:
leukocytosis:
- immediate release from ___ ___
- prolonged infection stimulates bone marrow ___ cells

bone marrow
stem

27

systemic manifestation of inflammation:
- sleepiness
- ___ blood pressure
- ___ fibrinogen
- __ erythrocyte sedimentation rate

decrease
increase
increase

28

systemic manifestation of inflammation:
failure of localization (lymph involvement)
- regional lymph nodes (__ line of defense) --> failure of localization --> reticuloendothelial cells (___ line of defense)

2nd
3rd