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T3- Patho unit 1 > 1. wk 5 inflammation > Flashcards

1. wk 5 inflammation Flashcards

stopped at S; 37 (66 cards)

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1
Q

___: vascular and cellular response whose purpose is to localize / elimainate the injurious agents

A

inflammation

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2
Q

what are the two types of inflammation

A

acute

chronic

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3
Q

___: transient process that occurs within few min of injury and lasts for short time

A

acute inflammation

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4
Q

infectious agents are (4)

A

bact
viruses
parasites
protozoa

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5
Q

name 5 causes of inflam

A
  1. infectious agents
  2. hypersensitivity rxn
  3. physical agents
  4. chem agents
  5. tiss necrosis
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6
Q

___: redness due to blood vessel dilation

A

rubor

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7
Q

___: pain due to incr. pressure by exudate

A

dolor

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8
Q

___: increa. heat due to increase in blood flow

A

calor

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9
Q

___: swelling due to acc of exudate

A

tumor

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10
Q

___: loss of fxn due to pain and tiss damage

A

funtio laesa

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11
Q

What are two mediators of dolor

A

bradykinin

prostaglandin

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12
Q

what are the 5 cardinal signs of acute inflam

A 
rubor 
dolor 
calor
tumor 
functio laesa
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13
Q

____: fluid, protein, and blood escaping from the vascular system into tiss

A

exudation

aka edema

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14
Q

____: ultrafiltrate of blood and plasma, results from imbalance across vascular endothelium

A

transudate

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15
Q

____: excess of fluid in the interstitial tis of body cavitites (can be exudate or transudate)

A

edema

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16
Q

______: purulent inflam exudate abundant

A

pus

abundant in leukocytes and cell debris

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17
Q

edema can be ___ or ___

A

exudate or transudate

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18
Q

_____ will only form in a bact. infection

A

pus

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19
Q

There is normal permeability and increa. hydrostatic pressure in ______

A

trandsudate

increase permeability in exudate

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20
Q

There is an increase in permeability in _____

A

exudate

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21
Q

_____ only has albumin

A

trandsudate

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22
Q

After a strike to the skin there is a white line bc of _______

A

arteriolar vasoconstriction

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23
Q

What is involved in “triple Response”

A
  1. flush (due to cap. dialation)
  2. flare (due to arteriolar dilation
  3. wheal (due to edema caused by incr. permeability )
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24
Q

the flush during triple response is due to _____

A

capillary dilation

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25
the flare during triple response is due to ____
arteriolar dilation
26
the wheal during triple response is due to _____
edema caused by incr. permeability
27
vascular changes is called _____
hemohynamics
28
there is ____ leakage , ___ for a long time till damage vessel is repaired during "immediate sustained (prolonged) leakage
immediate leakage , sustained for a long time
29
leakage begins after ___ & lasts for _____ during "delayed systained leakage"
begins 2-12 hrs lasts: several hrs or days lates awhile to begin and a while to end
30
as blood flow slows, ___ fall out of the central column and roll along the endothelium
neutrophils
31
______: is the neutrophils adhering to endothelium by surface adhesion mole
pavementing
32
during _______ neutophils insert pseudopods in intercellular jxn , squeeze their way, & exscpe into extravascular space
emigration
33
____: the passage of blood cells (WBC) through intact cap. walls and into surrounding tis
diapedesis
34
there is recognition of the phagocyte by attachment to agent either directly or indirectly by ____
IgG or complement (opsonization )
35
cytoplasm of a phagocyte surrounds agent, encloses it into a membrane bound vacuole called _____
phagosome
36
_____emigrate first, and then are later replaced by monocytes
neutraphils
37
______: neutrophils mnove toward site of injury along conc. gradient of chemotact agents
chemotaxis
38
if inflam process and lynmph nodes fail to defend against bact. it goes into the ______
venous circulation (bad!) --> bacteremia septicemia
39
what is the first line of defense after damage
inflam process
40
if the inflam process fails to stop the damage , the bact. is carried to the _____
lymph node to be filtered
41
fxn of neutrophils
phagocytosis
42
_____ make up the majority of WBC
neutrophils (60-70%)
43
what is the 1st inflam cell to respond
neutrophils
44
_____ respond to allergy and parasitic infections
eosinophils
45
____ make up 1-4% of total WBC
eosinophils
46
_____cyte respond to chronic inflam & acute viral or fungal infections
lymphocytes | 25-30% of WBC
47
_____cyte make up 25-30% of WBC
lymphocytes
48
fxn of monocytes is ____
phagocytosis
49
___cyte are long lived. they replace neutrophils 1-2 days later
monocyte
50
What is the plasmatic zone during inflm
layer of plasma protecting endoth.
51
RBC sludging during inflam is called ___
Rouleaux formation
52
_____ mechanism of intracellular killing: phagocytosis stim cellular oxidative mechanism (respiratory burst)
oxygen dependent mechanism
53
_____mechanism of intracellular killing: phagosome fuses with lysosome
oxygen independent
54
What are 2 vasoactive amines
histamine and serotonin | source: mast cells, basophils, platets
55
Action of histamine and serotonin (vasoactive amines)
dilation of arterioles incr permeability short lived , immediate
56
Fxn of plasma proteaase bradykinins
dilation of arterioles incr permeability ** pain short lived
57
activation of ____ leads to production of thrombin from prothrombin
factor XII (hageman factor)
58
What arachidonic acid cycle is blocked by aspirin and ibuprofen
cyclooxygenase cycle
59
fxn of the lipoxygenase cycle (under the arachidonic acid)
leukotrienes : increase permeability , chemotasix
60
fxn of the cyclooxygenase cycle
prostagladin (vesodil) thromboxane (vasocon) prostacyclin (vasodilation)
61
what are 4 products released by leukoproducts
02 derived free radicals lysosomal enzymes platlet activating factor cytokinase
62
tumor necrosis agent
TNF
63
fxn of the hageman factor activation
clotting system | kinin system
64
What cells are histamine and serotonin derived from
mast cells blood basophils blood platelets
65
3 systemic clinical signs of inflammation
fever change in WBC count incr. erythrocyte sedimentation rate
66
healing as a result of inflammation will result in (3)
complete resolution healing by scar progression to chronic inflam

T3- Patho unit 1 (14 decks)

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