10) Dermatopathology Flashcards

(33 cards)

1
Q

What is the class for Hydrocortisone

A

Steroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the therapeutics for Hydrocortisone

A

Dermatitis, psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the important side effects for Hydrocortisone

A

Atrophy/thinning of skin (collagen), stretch marks, talangiectasias, acne, cataract or glaucoma if applied near eye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the other side effects for Hydrocortisone

A

Systemically, affects hypothalamic-pituitary-adrenal axis –> growth retardation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the miscellaneous for Hydrocortisone

A

Seven classes, w/class I being the strongest and class VII being the weakest; side effects may be permanent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the class for Cyclosporine

A

Immunosuppressant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the therapeutics for Cyclosporine

A

Inflammatory conditions (psoriasis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the important side effects for Cyclosporine

A

Raise blood pressure, damage kidneys if used long-term

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the class for Methotrexate

A

Folate analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the mechanism for Methotrexate

A

Inhibits DHFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the therapeutics for Methotrexate

A

Inflammatory conditions (psoriasis), conditions needing immunosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the important side effects for Methotrexate

A

Hepatotoxicity (develops slowly, can give up to 4.5 g over life); pulmonary toxicity (develops quickly); leukopenia; rarely, renal toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the other side effects for Methotrexate

A

Nausea, vomiting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the miscellaneous for Methotrexate

A

PO, IM (1/week); any drug increasing unbound protein may cause methotrexate toxicity (sulfa, salicylates, TCN, phenytoin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the mechanism for Biologics

A

Block TNF-a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the therapeutics for Biologics

A

Inflammatory conditions, arthritis

17
Q

What are the important side effects for Biologics

A

Few (may unmask neurologic disease, latent infections (must do PPDs), malignancies)

18
Q

What are the miscellaneous for Biologics

19
Q

What is the class for UV light therapy

A

UVA, UVB, UVC

20
Q

What is the mechanism for UV light therapy

A

Immunosuppression of T-cells via type I or type II reactions –> mono- or bifunctional adducts in DNA

21
Q

What are the therapeutics for UV light therapy

A

Inflammatory conditions: atopic dermatitis, CTCL, lichen planus, psoriasis (not useful for non-inflammatory conditions)

22
Q

What are the important side effects for UV light therapy

A

Skin cancer, thinning/leathering of skin

23
Q

What are the miscellaneous for UV light therapy

A

Usually used with psoralens (photosensitizing agents that increase efficacy); phenothiazines, thiazides, sulfonamides, NSAIDs, tetracycline, benzodiazapenes also sensitize skin to light therapy

24
Q

What is the class for Isotretinoin (Accutane)

25
What is the mechanism for Isotretinoin (Accutane)
Stimulate epithelial cell turnover; also anti-inflammatory
26
What are the therapeutics for Isotretinoin (Accutane)
Acne
27
What are the important side effects for Isotretinoin (Accutane)
Teratogenic effects (washes out in three weeks)
28
What are the miscellaneous for Isotretinoin (Accutane)
Good as adjunct to other therapies
29
What is the class for Acitretin (Soriatane)
Retinoid
30
What is the mechanism for Acitretin (Soriatane)
Stimulate epithelial cell turnover; also anti-inflammatory
31
What are the therapeutics for Acitretin (Soriatane)
Psoriasis
32
What are the important side effects for Acitretin (Soriatane)
Teratogenic effects (stays in fat stores for three years)
33
What are the miscellaneous for Acitretin (Soriatane)
Good as adjunct to other therapies