10) Dermatopathology Flashcards Preview

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Flashcards in 10) Dermatopathology Deck (33)
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1

What is the class for Hydrocortisone

Steroid

2

What are the therapeutics for Hydrocortisone

Dermatitis, psoriasis

3

What are the important side effects for Hydrocortisone

Atrophy/thinning of skin (collagen), stretch marks, talangiectasias, acne, cataract or glaucoma if applied near eye

4

What are the other side effects for Hydrocortisone

Systemically, affects hypothalamic-pituitary-adrenal axis --> growth retardation

5

What are the miscellaneous for Hydrocortisone

Seven classes, w/class I being the strongest and class VII being the weakest; side effects may be permanent

6

What is the class for Cyclosporine

Immunosuppressant

7

What are the therapeutics for Cyclosporine

Inflammatory conditions (psoriasis)

8

What are the important side effects for Cyclosporine

Raise blood pressure, damage kidneys if used long-term

9

What is the class for Methotrexate

Folate analog

10

What is the mechanism for Methotrexate

Inhibits DHFR

11

What are the therapeutics for Methotrexate

Inflammatory conditions (psoriasis), conditions needing immunosuppression

12

What are the important side effects for Methotrexate

Hepatotoxicity (develops slowly, can give up to 4.5 g over life); pulmonary toxicity (develops quickly); leukopenia; rarely, renal toxicity

13

What are the other side effects for Methotrexate

Nausea, vomiting

14

What are the miscellaneous for Methotrexate

PO, IM (1/week); any drug increasing unbound protein may cause methotrexate toxicity (sulfa, salicylates, TCN, phenytoin)

15

What is the mechanism for Biologics

Block TNF-a

16

What are the therapeutics for Biologics

Inflammatory conditions, arthritis

17

What are the important side effects for Biologics

Few (may unmask neurologic disease, latent infections (must do PPDs), malignancies)

18

What are the miscellaneous for Biologics

Costly

19

What is the class for UV light therapy

UVA, UVB, UVC

20

What is the mechanism for UV light therapy

Immunosuppression of T-cells via type I or type II reactions --> mono- or bifunctional adducts in DNA

21

What are the therapeutics for UV light therapy

Inflammatory conditions: atopic dermatitis, CTCL, lichen planus, psoriasis (not useful for non-inflammatory conditions)

22

What are the important side effects for UV light therapy

Skin cancer, thinning/leathering of skin

23

What are the miscellaneous for UV light therapy

Usually used with psoralens (photosensitizing agents that increase efficacy); phenothiazines, thiazides, sulfonamides, NSAIDs, tetracycline, benzodiazapenes also sensitize skin to light therapy

24

What is the class for Isotretinoin (Accutane)

Retinoid

25

What is the mechanism for Isotretinoin (Accutane)

Stimulate epithelial cell turnover; also anti-inflammatory

26

What are the therapeutics for Isotretinoin (Accutane)

Acne

27

What are the important side effects for Isotretinoin (Accutane)

Teratogenic effects (washes out in three weeks)

28

What are the miscellaneous for Isotretinoin (Accutane)

Good as adjunct to other therapies

29

What is the class for Acitretin (Soriatane)

Retinoid

30

What is the mechanism for Acitretin (Soriatane)

Stimulate epithelial cell turnover; also anti-inflammatory