5) Rheumatoid Arthritis and Gout Flashcards Preview

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Flashcards in 5) Rheumatoid Arthritis and Gout Deck (97)
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1

What is the class for Indomethacin (Indocin)

Non-selective NSAID

2

What is the mechanism for Indomethacin (Indocin)

Eliminate pain; reduce inflammation (but does not slow disease progression)

3

What are the therapeutics for Indomethacin (Indocin)

Rheumatoid arthritis; acute gouty arthritis

4

What are the important side effects for Indomethacin (Indocin)

Gastric and duodenal ulcers

5

What is the class for Naproxen (Aleve)

Non-selective NSAID

6

What is the mechanism for Naproxen (Aleve)

Eliminate pain; reduce inflammation (but does not slow disease progression)

7

What are the therapeutics for Naproxen (Aleve)

Rheumatoid arthritis; acute gouty arthritis

8

What are the important side effects for Naproxen (Aleve)

Gastric and duodenal ulcers

9

What is the class for COX-2 inhibitors

Selective NSAID

10

What is the mechanism for COX-2 inhibitors

Eliminate pain; reduce inflammation (but does not slow disease progression)

11

What are the therapeutics for COX-2 inhibitors

Superseding conventional NSAIDs for rheumatoid arthritis

12

What are the important side effects for COX-2 inhibitors

50% fewer gastric and duodenal ulcers than traditional NSAIDs

13

What is the class for Quinolones

DMARD (antimalarial)

14

What is the mechanism for Quinolones

Reduces T-cell activation & chemotaxis

15

What are the therapeutics for Quinolones

Rheumatoid arthritis, SLE

16

What are the important side effects for Quinolones

Retinal damage (chloroquine)

17

What are the miscellaneous for Quinolones

Used for patients who no longer respond to NSAIDS or can't tolerate other DMARDs

18

What is the class for Glucocorticoids
(Corticosteroids)

DMARD

19

What is the mechanism for Glucocorticoids
(Corticosteroids)

1. Inhibits phospholipase A2 (inhibiting release of arachidonic acid and, thus, formation of prostaglandins)
2. Inhibits cytokine production (which prevents induction of COX-2)

20

What are the therapeutics for Glucocorticoids
(Corticosteroids)

Rheumatoid arthritis; acute gouty arthritis (intraarticular injection for relief of acute monoarticular gout)

21

What are the important side effects for Glucocorticoids
(Corticosteroids)

Cushingoid symptoms

22

What are the miscellaneous for Glucocorticoids
(Corticosteroids)

Started initially (fast acting) before other drugs become effective
Can give orally or intra-articularly

23

What is the class for Sulfasalazine (Azulfidine)

DMARD

24

What is the mechanism for Sulfasalazine (Azulfidine)

Likely inhibition of IL-1 & TNF-alpha release

25

What are the therapeutics for Sulfasalazine (Azulfidine)

Rheumatoid arthritis

26

What are the important side effects for Sulfasalazine (Azulfidine)

N/V, skin rashes, neutropenia (30% of patient discontinue drug)

27

What are the other side effects for Sulfasalazine (Azulfidine)

Headaches

28

What are the miscellaneous for Sulfasalazine (Azulfidine)

Acts more quickly than other drugs

29

What is the class for Methotrexate (Trexall)

DMARD
(Immunosuppressive)

30

What is the mechanism for Methotrexate (Trexall)

1. Inhibition of aminoimidazolecarboxamide (AICAR) transformylase and
thymidylate synthetase, with secondary effects on PMN chemotaxis
2. Causes adenosine accumulation, which inhibits inflammation