7) Histamine, Serotonin, and Antagonists Flashcards Preview

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Flashcards in 7) Histamine, Serotonin, and Antagonists Deck (83)
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1

What is the mechanism for H1 receptor antagonist

H1 receptor antagonist; rapidly absorbed orally, widely distributed, rapidly metabolized via liver microsomes

2

What are the therapeutics for H1 receptor antagonist

Allergic reactions, motion sickness, nausea and vomiting in pregnancy, sleep aids

3

What are the important side effects for H1 receptor antagonist

Sedation, anti-muscarinic action, poisoning (especially children) with convulsions, allergy, local anesthesia

4

What are the miscellaneous for H1 receptor antagonist

Older agents cross CNS to cause central effects

5

What is the class for Diphenhydramine (Benadryl)

Ether/ethanolamine derivitive

6

What is the mechanism for Diphenhydramine (Benadryl)

H1 receptor antagonist

7

What are the important side effects for Diphenhydramine (Benadryl)

Anti-muscarinic, sedating

8

What is the class for Tripelennamine (Pyribenzamine)

Ethylenediamine derivitive

9

What is the mechanism for Tripelennamine (Pyribenzamine)

H1 receptor antagonist

10

What are the therapeutics for Tripelennamine (Pyribenzamine)

OTC sleep aid

11

What is the class for Cyclizine (Marezine)

Piperazine derivative

12

What is the mechanism for Cyclizine (Marezine)

H1 receptor antagonist

13

What are the therapeutics for Cyclizine (Marezine)

Motion sickness

14

What is the class for Promethazine (Phenergan)

Phenothiazine derivative

15

What is the mechanism for Promethazine (Phenergan)

H1 receptor antagonist

16

What are the therapeutics for Promethazine (Phenergan)

Antiemetic

17

What are the important side effects for Promethazine (Phenergan)

Anti-muscarinic, sedating

18

What is the class for Chlorpheniramine (Chlor-Trimeton)

Alkylamine derivitive

19

What is the mechanism for Chlorpheniramine (Chlor-Trimeton)

H1 receptor antagonist

20

What are the therapeutics for Chlorpheniramine (Chlor-Trimeton)

Component of "cold" medications

21

What are the important side effects for Chlorpheniramine (Chlor-Trimeton)

Less sedating

22

What is the class for Loratadine (Claritin)

Piperidine derivitive

23

What is the mechanism for Loratadine (Claritin)

2nd generation H1 receptor antagonist

24

What are the therapeutics for Loratadine (Claritin)

Allergic rhinitis

25

What are the important side effects for Loratadine (Claritin)

No sedation

26

What are the other side effects for Loratadine (Claritin)

Cardiovascular effects (rare, with high doses)

27

What are the miscellaneous for Loratadine (Claritin)

Poorly crosses BBB, so fewer central and side effects

28

What is the class for Fexofenadine (Allegra)

Piperidine derivitive

29

What is the mechanism for Fexofenadine (Allegra)

2nd generation H1 receptor antagonist

30

What are the therapeutics for Fexofenadine (Allegra)

Allergic rhinitis