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Pharm U2 > 2) Cholinergic Receptor-Inhibitors > Flashcards

2) Cholinergic Receptor-Inhibitors Flashcards

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1
Q

What is the class for Atropine

A

Tertiary amine antimuscarinic

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2
Q

What is the mechanism for Atropine

A

Blocks muscarinic receptors

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3
Q

What are the therapeutics for Atropine

A

Mydriasis; cycloplegia

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4
Q

What are the important side effects for Atropine

A

General block of muscarinic functions

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5
Q

What is the class for Scopolamine (Transderm-Scop)

A

Tertiary amine antimuscarinic

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6
Q

What is the mechanism for Scopolamine (Transderm-Scop)

A

Blocks muscarinic receptors

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7
Q

What are the therapeutics for Scopolamine (Transderm-Scop)

A

Prevent or reduce motion sickness

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8
Q

What are the important side effects for Scopolamine (Transderm-Scop)

A

General block of muscarinic functions

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9
Q

What is the class for Dicyclomine (Bentyl)

A

Tertiary amine antimuscarinic

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10
Q

What is the mechanism for Dicyclomine (Bentyl)

A

Blocks muscarinic receptors

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11
Q

What are the therapeutics for Dicyclomine (Bentyl)

A

Reduce transient hypermotility

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12
Q

What are the important side effects for Dicyclomine (Bentyl)

A

General block of muscarinic functions

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13
Q

What is the class for Tropicamide (Mydriacyl)

A

Tertiary amine antimuscarinic

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14
Q

What is the mechanism for Tropicamide (Mydriacyl)

A

Blocks muscarinic receptors

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15
Q

What are the therapeutics for Tropicamide (Mydriacyl)

A

Mydriasis; cycloplegia

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16
Q

What are the important side effects for Tropicamide (Mydriacyl)

A

General block of muscarinic functions

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17
Q

What are the miscellaneous for Tropicamide (Mydriacyl)

A

Very rapidly metabolized

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18
Q

What is the class for Tolterodine (Detrol)

A

Tertiary amine antimuscarinic

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19
Q

What is the mechanism for Tolterodine (Detrol)

A

Blocks muscarinic receptors

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20
Q

What are the therapeutics for Tolterodine (Detrol)

A

Treat transient cystitis; postoperative bladder spasms; incontinence

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21
Q

What are the important side effects for Tolterodine (Detrol)

A

General block of muscarinic functions

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22
Q

What is the class for Benztropine (Cogentin)

A

Tertiary amine antimuscarinic

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23
Q

What is the mechanism for Benztropine (Cogentin)

A

Blocks muscarinic receptors

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24
Q

What are the therapeutics for Benztropine (Cogentin)

A

Treat manifestations of Parkinson’s disease

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25
What are the important side effects for Benztropine (Cogentin)
General block of muscarinic functions
26
What are the miscellaneous for Benztropine (Cogentin)
Crosses BBB
27
What is the class for Ipratropium (Atrovent)
Quarternary amine antimuscarinic
28
What is the mechanism for Ipratropium (Atrovent)
Blocks muscarinic receptors
29
What are the therapeutics for Ipratropium (Atrovent)
Bronchodilation in asthma or COPD
30
What are the important side effects for Ipratropium (Atrovent)
General block of muscarinic functions
31
What is the class for Tiotropium (Spiriva)
Quarternary amine antimuscarinic
32
What is the mechanism for Tiotropium (Spiriva)
Blocks muscarinic receptors
33
What are the therapeutics for Tiotropium (Spiriva)
Bronchodilation in asthma or COPD
34
What are the important side effects for Tiotropium (Spiriva)
General block of muscarinic functions
35
What are the miscellaneous for Tiotropium (Spiriva)
Longer acting than ipratropium
36
What is the class for Hexamethonium (Methium)
Ganglionic blocker
37
What is the mechanism for Hexamethonium (Methium)
Blocks ganglionic (Nn) receptor and sympathetic tone
38
What are the therapeutics for Hexamethonium (Methium)
Hypertensive crisis; "Bloodless" field surgery
39
What are the miscellaneous for Hexamethonium (Methium)
Rarely used
40
What is the class for Mecamylamine
Ganglionic blocker
41
What is the mechanism for Mecamylamine
Blocks ganglionic (Nn) receptor and sympathetic tone
42
What are the therapeutics for Mecamylamine
Hypertensive crisis; "Bloodless" field surgery
43
What are the miscellaneous for Mecamylamine
Rarely used
44
What is the class for Succinylcholine (Anectine)
Depolarizing blocker
45
What is the mechanism for Succinylcholine (Anectine)
Overstimulation of nicotinic receptor, leading to desensitization of muscle unit to further ACh stimulation
46
What are the therapeutics for Succinylcholine (Anectine)
Brief procedures (e.g., tracheal intubation, reset dislocated joints)
47
What are the important side effects for Succinylcholine (Anectine)
Respiratory paralysis; disturbance of autonomic function
48
What are the miscellaneous for Succinylcholine (Anectine)
Produces flaccid paralysis within 1 minute
49
What is the class for Tubocurarine (Curare)
Nondepolarizing blocker
50
What is the mechanism for Tubocurarine (Curare)
Blocks nicotinic (Nm) receptor
51
What are the therapeutics for Tubocurarine (Curare)
Muscle relaxant for surgery w/o deep anesthesia
52
What are the important side effects for Tubocurarine (Curare)
Respiratory paralysis; disturbance of autonomic function
53
What are the miscellaneous for Tubocurarine (Curare)
Lasts 30-60 minutes
54
What is the class for Mivacurium (Mivacron)
Nondepolarizing blocker
55
What is the mechanism for Mivacurium (Mivacron)
Blocks nicotinic (Nm) receptor
56
What are the therapeutics for Mivacurium (Mivacron)
Muscle relaxant for surgery w/o deep anesthesia
57
What are the important side effects for Mivacurium (Mivacron)
Respiratory paralysis; disturbance of autonomic function
58
What are the miscellaneous for Mivacurium (Mivacron)
Rapidly hydrolyzed, short acting
59
What is the class for Botulinum toxin A (Botox)
Local paralytic
60
What is the mechanism for Botulinum toxin A (Botox)
Blocks vesicle fusion and ACh release on presynaptic terminal by degrading SNAP-25
61
What are the therapeutics for Botulinum toxin A (Botox)
Reduce frown lines and wrinkles; achalasia; strabismus; oromandibular dystonia

Pharm U2 (11 decks)

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