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Flashcards in 6) Malaria Deck (44)
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1

What is the class for Quinine (Qualaquin)

Quinolone derivitive

2

What is the mechanism for Quinine (Qualaquin)

Accumulate in parasite’s food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive proteases

3

What are the therapeutics for Quinine (Qualaquin)

Prophylaxis, treatment of acute malarial attacks

4

What are the important side effects for Quinine (Qualaquin)

Cinchonism, hypotension, hypoglycemia, abortion, arrhythmias

5

What are the miscellaneous for Quinine (Qualaquin)

Also called quinidine (used in anti-arrhythmias)

6

What is the class for Chloroquine (Aralen)

Quinolone derivitive

7

What is the mechanism for Chloroquine (Aralen)

Accumulate in parasite’s food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive proteases

8

What are the therapeutics for Chloroquine (Aralen)

Prophylaxis, treatment of acute malarial attacks

9

What are the important side effects for Chloroquine (Aralen)

Itching (Africans), retinitis (rare)

10

What is the class for Hydroxychloroquine (Plaquenil)

Quinolone derivitive

11

What is the mechanism for Hydroxychloroquine (Plaquenil)

Accumulate in parasite’s food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive proteases

12

What are the therapeutics for Hydroxychloroquine (Plaquenil)

Prophylaxis, treatment of acute malarial attacks

13

What is the class for Mefloquine (Lariam)

Quinolone derivitive

14

What is the mechanism for Mefloquine (Lariam)

Accumulate in parasite’s food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive proteases

15

What are the therapeutics for Mefloquine (Lariam)

Prophylaxis, treatment of acute malarial attacks

16

What is the class for Primaquine (Primaryl)

Quinolone derivitive

17

What is the mechanism for Primaquine (Primaryl)

Forms quinolone-quinone intermediates that oxidize schizont membranes

18

What are the therapeutics for Primaquine (Primaryl)

Prophylaxis, treatment of acute malarial attacks

19

What are the important side effects for Primaquine (Primaryl)

Hemolysis (G6PD), methemoglobinemia

20

What are the other side effects for Primaquine (Primaryl)

Fever, nausea, vomiting

21

What are the miscellaneous for Primaquine (Primaryl)

Only drug that inhibits exoerythrocytic schyzogony

22

What is the mechanism for Amantadine (Symmetrel)

Positive charge helps chloroquine overcome chloroquine-resistant malaria vacuoles; point mutations against amantadine return bacteria to chloroquine-sensitivity

23

What is the class for Artesunate

Artemisinin compound

24

What is the mechanism for Artesunate

Specifically and selectively inhibit SERCA of P. falciparum

25

What are the important side effects for Artesunate

Neurotoxicity, prolongation of QT interval

26

What is the class for Artemether

Artemisinin compound

27

What is the mechanism for Artemether

Specifically and selectively inhibit SERCA of P. falciparum

28

What is the class for Lumefantrine

Aminoalcohol

29

What are the therapeutics for Lumefantrine

Used in combination w/artemether (called Coartem)

30

What are the miscellaneous for Lumefantrine

Also called benflumentol