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Flashcards in Auto I - receptor types Deck (32)
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1

What are the typical locations for M1

CNS neurons, sympathetic postganglionic neurons, some presynaptic sites

2

What is the result of ligand binding for M1

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M3 and M5)

3

What are the typical locations for M2

Myocardium, smooth muscle, some presynaptic sites; CNS neurons

4

What is the result of ligand binding for M2

Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M4)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

5

What are the typical locations for M3

Exocrine glands, vessels (smooth muscle and endothelium); CNS neurons

6

What is the result of ligand binding for M3

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M5)

7

What are the typical locations for M4

CNS neurons; possibly vagal nerve endings

8

What is the result of ligand binding for M4

Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M2)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

9

What are the typical locations for M5

Vascular endothelium, especially cerebral vessels; CNS neurons

10

What is the result of ligand binding for M5

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M3)

11

What are the typical locations for Nicotinic N

postganglionic neurons, some presynaptic cholinergic terminals

12

What is the result of ligand binding for Nicotinic N

opening of Na, K channels, depolarization

13

What are the typical locations for Nicotinic M

Skeletal muscle neuromuscular end plates

14

What is the result of ligand binding for Nicotinic M

opening of Na, K channels, depolarization

15

What are the typical locations for Alpha 1

postsynaptic effector cells, especially smooth muscle

16

What is the result of ligand binding for Alpha 1

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium

17

What are the typical locations for Alpha 2

presynaptic adrenergic nerve terminals, platelets, adipocytes and smooth muscle

18

What is the result of ligand binding for Alpha 2

Inhibition of adenylyl cyclase, decreased cAMP
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

19

What are the typical locations for Beta 1

postsynaptic effector cells, especially heart, lipocytes, brain; presynaptic adrenergic and cholinergic nerve terminals, juxtaglomerular apparatus of the renal tubules, cilliary body epithelium

20

What is the result of ligand binding for Beta 1

stimulation of adenylyl cyclase, increased cAMP
Gs to AC to cAMP

21

What are the typical locations for Beta 2

postsynaptic effector cells, especially smooth muscle and cardiac muscle

22

What is the result of ligand binding for Beta 2

stimulation of adenylyl cyclase, increased cAMP, Activates cardiac G1 under some conditions
Gs to AC to cAMP

23

What are the typical locations for Beta 3

postsynaptic effector cells, epsecially lipocytes and heart

24

What is the result of ligand binding for Beta 3

stimulation of adenylyl cyclase, increased cAMP
Gs to AC to cAMP

25

What are the typical locations for D1 (DA1), D5

Brain; effector tissues, especially smooth muscle of the renal vascular bed

26

What is the result of ligand binding for D1 (DA1), D5

stimulation of adenylyl cyclase, increased cAMP

27

What are the typical locations for D2 (DA2)

Brain; effector tissues, especially smooth muscl, presynaptic nerve terminals

28

What is the result of ligand binding for D2 (DA2)

inhibition of adenylyl cyclase; increased potassium conductance D3

29

What are the typical locations for D3

brain

30

What is the result of ligand binding for D3

Inhibition of adenylyl cyclase D4