3) Dyshemoglobinemias Flashcards Preview

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Flashcards in 3) Dyshemoglobinemias Deck (11)
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1

What are the therapeutics for Hyperbaric oxygen

Prevents lipid peroxidation (?) and delayed neurologic sequelae in CO poisoning

2

What is the mechanism for Nitrites

Turns RBC hemoglobin to methemoglobin; CN moves from Fe(3+) on cytochromes to those in RBCs creating cyanomethemoglobin

3

What are the miscellaneous for Nitrites

Dangerous in concurrent CO poisoning

4

What is the mechanism for Sodium thiosulfate

Enhances normal metabolism of cyanide via rhodanase

5

What is the mechanism for Hydroxycobalamin (Cyanokit)

Binds with cyanide --> cyanocobalamin (B12)

6

What are the therapeutics for Hydroxycobalamin (Cyanokit)

Smoke inhalation victims not improving with supportive care, cyanide exposure, nitroprusside at risk patients

7

What are the miscellaneous for Hydroxycobalamin (Cyanokit)

Give concurrently with sodium thiosulfate

8

What is the mechanism for Methylene blue (Urolene Blue)

Cofactor of NADPH reductase; gains electron, donates directly to reduce methemoglobin

9

What are the therapeutics for Methylene blue (Urolene Blue)

Methemoglobinemia >20-30%, or with symptoms

10

What are the important side effects for Methylene blue (Urolene Blue)

Hemolytic anemia (weak oxidizing capability)

11

What are the other side effects for Methylene blue (Urolene Blue)

Painful at injection site, dyspnea, restlessness, tremor, precordial pain, and apprehension