9) Thrombosis Flashcards Preview

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Flashcards in 9) Thrombosis Deck (91)
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1

What is the class for Unfractionated heparin

Indirect thrombin inhibitors

2

What is the mechanism for Unfractionated heparin

Bind antithrombin, potentiating formation of antithrombin-coagulation factor complex (Xa, IIa)

3

What are the therapeutics for Unfractionated heparin

Prevention and treatment of venous thromboembolism

4

What are the important side effects for Unfractionated heparin

HIT, bleeding

5

What are the other side effects for Unfractionated heparin

Osteoporosis

6

What are the miscellaneous for Unfractionated heparin

Given parenterally; monitored via PTT (want 2-2.5X normal value); reversed by protamine

7

What is the class for Dalteparin (Fragmin)

Indirect thrombin inhibitors

8

What is the mechanism for Dalteparin (Fragmin)

LMWH that inhibits thrombin less effectively than Xa

9

What are the therapeutics for Dalteparin (Fragmin)

Prevent thrombosis and embolism from clots

10

What are the important side effects for Dalteparin (Fragmin)

Bleeding

11

What are the miscellaneous for Dalteparin (Fragmin)

Monitored by heparin assay (anti-factor Xa); longer half-life than heparin (1-2/day); reversed by protamine

12

What is the class for Enoxaparin (Lovenox)

Indirect thrombin inhibitors

13

What is the mechanism for Enoxaparin (Lovenox)

LMWH that inhibits thrombin less effectively than Xa

14

What are the therapeutics for Enoxaparin (Lovenox)

Drug of choice in pregnancy; prevention and treatment of venous thromboembolism

15

What are the important side effects for Enoxaparin (Lovenox)

HIT; bleeding; osteoporosis and thrombocytopenia uncommon

16

What are the miscellaneous for Enoxaparin (Lovenox)

Can be monitored by heparin assay (anti-factor Xa); longer half-life than heparin (1-2/day); reversed by protamine

17

What is the class for Tinzaparin (Innohep)

Indirect thrombin inhibitors

18

What is the mechanism for Tinzaparin (Innohep)

LMWH that inhibits thrombin less effectively than Xa

19

What are the important side effects for Tinzaparin (Innohep)

HIT; osteoporosis and thrombocytopenia uncommon

20

What are the other side effects for Tinzaparin (Innohep)

Bleeding

21

What are the miscellaneous for Tinzaparin (Innohep)

Monitored by heparin assay (anti-factor Xa); longer half-life than heparin (1-2/day); reversed by protamine

22

What is the class for Fondaparinux (Arixtra)

Indirect thrombin inhibitors

23

What is the mechanism for Fondaparinux (Arixtra)

Synthetic polysaccharide that binds active site of antithrombin; inhibits Xa

24

What are the therapeutics for Fondaparinux (Arixtra)

Given for HIT

25

What are the other side effects for Fondaparinux (Arixtra)

Bleeding

26

What are the miscellaneous for Fondaparinux (Arixtra)

No antidote

27

What is the class for Warfarin (Coumadin)

Vitamin K antagonist

28

What is the mechanism for Warfarin (Coumadin)

Blocks vitamin K-dependent gamma-carboxylation of factors II, VII, IX, X, Protein C and S (does not affect already synthesized factors)

29

What are the therapeutics for Warfarin (Coumadin)

Long-term anticoagulation

30

What are the important side effects for Warfarin (Coumadin)

Thrombosis (Protein C depression)