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Flashcards in 8) Inflammation Deck (64)
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1

What is the class for Acetylsalicylic acid (ASA, Aspirin)

Salicylate

2

What is the mechanism for Acetylsalicylic acid (ASA, Aspirin)

Acetyl-salicylic acid irreversibly acetylates COX-1 and -2; metabolite (salicylic acid) reversibly inhibits COX-1 and -2

3

What are the therapeutics for Acetylsalicylic acid (ASA, Aspirin)

Antiplatelet, analgesic and antipyretic, and anti-inflammatory (in ascending order of amount taken); often taken as a "baby aspirin" to prevent MI, CVA

4

What are the important side effects for Acetylsalicylic acid (ASA, Aspirin)

GI irritation, bleeding and anemia, hepatotoxicity, and salicylate toxicity

5

What are the other side effects for Acetylsalicylic acid (ASA, Aspirin)

Nephrotoxicity in elderly or hypovolemic patients; rare hypersensitivity reaction

6

What is the class for Diflunisal (Dolobid)

Salicylate

7

What is the mechanism for Diflunisal (Dolobid)

Difluorophenyl derivitive of salicylic acid, which reversibly inhibits COX-1 and -2

8

What are the therapeutics for Diflunisal (Dolobid)

Osteoarthritis, musculoskeletal strains/sprains, pain after dental extraction, and postepisiotomy pain

9

What are the important side effects for Diflunisal (Dolobid)

Fewer GI side effects and less effect on platelets than aspirin

10

What is the class for Acetaminophen (Tylenol)

Para-amino phenol

11

What is the mechanism for Acetaminophen (Tylenol)

Reversibly inhibits COX-1 and -2 (favors COX-1)

12

What are the therapeutics for Acetaminophen (Tylenol)

Analgesic and antipyretic effect similar to aspirin, but weak anti-inflammatory effects

13

What are the important side effects for Acetaminophen (Tylenol)

Renal tubular necrosis if chronically abused with other NSAIDs; hepatic necrosis with overdose

14

What are the other side effects for Acetaminophen (Tylenol)

GI irritation (less than aspirin)

15

What are the miscellaneous for Acetaminophen (Tylenol)

Poor function in presence of peroxides (as found in sites of inflammation); mostly metabolized via conjugation, but minor pathway via P450 enzymes may lead to toxic intermediate (N-acetyl-benzoquinoneimine)

16

What is the class for Indomethacin (Indocin)

Indole

17

What is the mechanism for Indomethacin (Indocin)

Reversibly inhibits COX-1 and -2 (favors COX-1)

18

What are the therapeutics for Indomethacin (Indocin)

Rhematoid arthritis (10X as potent as aspirin), ankylosing spondylitis, osteoarthritis, acute gout

19

What are the important side effects for Indomethacin (Indocin)

At times, thrombocytopenia, aplastic anemia, and severe frontal headaches

20

What are the other side effects for Indomethacin (Indocin)

Nephrotoxicity in elderly or hypovolemic patients

21

What is the class for Sulindac (Clinoril)

Indole

22

What is the mechanism for Sulindac (Clinoril)

Reversibly inhibits COX-1 and -2 (favors COX-1)

23

What are the therapeutics for Sulindac (Clinoril)

Rhematoid arthritis, ankylosing spondylitis, osteoarthritis, acute gout

24

What are the important side effects for Sulindac (Clinoril)

At times, thrombocytopenia, aplastic anemia, and severe frontal headaches

25

What are the other side effects for Sulindac (Clinoril)

Nephrotoxicity in elderly or hypovolemic patients

26

What are the miscellaneous for Sulindac (Clinoril)

Half as potent as indomethacin; side effects less frequent

27

What is the class for Ibuprofen (Advil, Motrin)

Proprionic acid dervitive

28

What is the mechanism for Ibuprofen (Advil, Motrin)

Reversibly inhibits COX-1 and -2 (favors COX-1)

29

What are the therapeutics for Ibuprofen (Advil, Motrin)

Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries

30

What are the important side effects for Ibuprofen (Advil, Motrin)

GI irritation; hepatotoxicity (less frequent than aspirin)