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House Microbiology > Viral infection of the skin > Flashcards

Viral infection of the skin Flashcards

1
Q

Viral infection of the skin

Viral diseases associated with _______ rash.

Viral disease associated with _______ rash.

A

maculopapular

vesicular

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2
Q

Viral diseases associated with maculopapular rash

List 4

A

Measles.
Rubella
Erythema infectiosum
Exanthem subitum

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3
Q

.
Rubella aka ____________

Erythema infectiosum aka _________ or __________.

Exanthem subitum aka __________ or _______

A

German measles

slapped cheek or fifth disease

roseola infantum or sixth disease)

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4
Q

German measles aka ______________

fifth disease aka________________

sixth disease aka ___________

A

Rubella

Erythema infectiosum

Exanthem subitum

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5
Q

Measles

Family : _________________

(Naked or Enveloped?) , with _____ glycoprotein spikes.

__________ spikes are the main neutralizing Ag.

Also mediate ________ of the virus to the ________________

A

paramyxoviridae ; Enveloped
two; Hemagglutinine spikes

adsorption ; host cell surface.

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6
Q

Measles

The viral genome is _____-RNA, with _______ polarity.

Virion contains the enzyme ____________.

_____ antigenic serotype.

A

SS-RNA ; negative

transcriptase.

One

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7
Q

Measles

Transmission : by _______ of __________.

Incubation Period : _____-_____ days.

Target group : ________.

A

inhalation ; respiratory droplets.

10 – 14 days.

children.

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8
Q

Clinical features of Measles

Prodromal : Fever, cough, (mild or severe?) ___________, nasal _______. Lasting ____ days.

A

mild conjunctivitis

discharge

1–3 days.

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9
Q

Clinical features of Measles

Kopliks spots :

(small or large?) , ____ papules with _____ central dot, appear on the ______________, their number ___ or ___, remain for a day or two.

They are diagnostic for measles.

A

small ; red ; white

side of the cheek

5 or 6

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10
Q

Clinical features of Measles

Rash : _____________ rash, first appear on the _____ then spread ________ward over the ______ and ___________.

A

maculopapular

face

downward

trunk

extremities.

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11
Q

Clinical features of Measles

The rash is _____, become _________ , last ________ days, then disappears leaving _______ discoloration of the skin and fine _________.

Recovery is (usual or unusual?)

A

red ; confluent

4 or 5

brownish ; desquamation.

usual

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12
Q

Prevention of measles

___________ vaccine (______).

Contains __________ measles, _______ and ___________ strains.
Administered in _____ dose.

Protection; (good or bad?) immunity.

Contraindications: should not be given to _________ and __________.

A

Live attenuated vaccine (MMR).

live attenuated measles, mumps and rubella virus

one dose ; good immunity.

pregnant women and immunocompromized.

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13
Q

Treatment & lab. diagnosis of measles

Treatment: there is _____________ drug therapy.

Lab. Diagnosis : By detection of _______ to measles virus.

A

no specific anti viral

IgM-Ab

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14
Q

Rubella (German measles)

Viral etiology: Rubella virus.
Family : ______viridae.
Genus : ______virus.

A

Toga

Rubivirus.

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15
Q

Rubella (German measles)

The virus is (naked or enveloped?) , ________ with _______ nucleocapsid.

The viral genome is ____-RNA with _________ polarity.

A

enveloped ; pleomorphic

helical ; SS-

positive polarity.

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16
Q

Rubella

Transmission :By _______ of ____________.

IP : ____ – ____ days.

Target group : _______.

A

inhalation of respiratory droplets

14 – 21

children.

17
Q

Clinical features of rubella

Prodromal : Fever, cough, nasal _________ , (mild or severe?) ___________.

A

discharge ; mild conjunctivitis.

18
Q

Clinical features of rubella

Rash : ————— rash, first appears on the _____ then spreads ____wards to ____ and _________.

The rash is ———, discrete, usually _______ after _____ hrs.

In nearly ______% of all infections there is no rash at all.

A

Maculopapular ;face

downwards ; trunk ; limbs.

red ; fades

48 hr 50%

19
Q

Clinical features of rubella

Rubella is characterized by enlargement of the __________ and _________ lymph nodes.

A

post- auricular and sub-occipital

20
Q

Prevention , treatment & lab Diagnosis of rubella

Vaccine : __________ vaccine (______).
Treatment : There is _______ viral therapy.
Lab. Diagnosis : By detection of _______ rubella virus.

A

Live attenuated vaccine (MMR).

no specific viral therapy.

IgM-Ab rubella virus.

21
Q

Viral diseases associated with vesicular rash

______ infection.
____ infection.
_______ (_______). _____.
Herpangina.
_______ & _______ disease.

A

HSV-1 infection.

HSV-2 infection.

Varicella (chickenpox). Zoster.

Hand-foot & mouth disease.

22
Q

Varicella (chickenpox)

Caused by ___________ virus (____).

The virus is transmitted by _________ of ________ and by _________ with the ________

Varicalla is a (common or rare?) childhood disease.

A

varicella-zoster virus (VZV).

inhalation of respiratory droplets

direct contact; skin lesions.

common

23
Q

Varicella (chickenpox)

_________ : is the primary illness.

__________ : is the recurrent form of the disease.

A

Varicella

Zoster

24
Q

Clinical features of varicella

IP : ____ days.

The disease starts with, fever, malaise, cough, headache, (localized or generalized?) ______ rash.

The rash first appears on the _______, then spreads to _____ and ______.

The rash appears in _____________.

Lesions progress from _______ to _______ to ________ , which eventually ______ to form ________.

The illness usually lasts for ______ days.

A

IP : 14-21 days.

generalized ; vesicular

trunk ; face ; limbs.

successive waves.

macules ; papules ; vesicles

ruptures ; ulcers.

4-7 days.

25
Q

Varicella Vaccine

_______ vaccine is available.

Administered in _____ dose.

Recommended for (children or adults?) of _____ years, ______ and _____ who have not yet had the diseases.

A

Live attenuated ; one

children ; 1-12 years

teenagers and adult

26
Q

Lab. diagnosis of varicella

Detection of Ig-___ antibody.

_______ from the base of the ______.

A

Ig-M

Scraping ; vesicles.

27
Q

Treatment of chicken pox

__________ drug therapy is necessary for immunocompetent children.

Severe cases of chickenpox is treated with ________.

A

No anti-viral drug therapy

acyclovir.

28
Q

Zoster (_______)

Zoster is (localized or generalized?) ________ rash.

It is a disease of (childhood or elderly?) .

It is due to __________ of ______, which is latent in the ______________

A

shingles

localized vesicular

elderly.

reactivation ; VZV

dorsal root ganglion.

29
Q

Complications of Zoster

__________.
______________.
__________.
______ zoster in the immunocompromized.

A

Meningitis.
Encephalitis.
Myelitis.
Disseminated zoster in the immunocompromized.

30
Q

Treatment of shingles

______ (zovirax), 800 mg,orally, ____ times daily for ______ days.

________ (Famvir), 500 mg, orally, _____ times daily for ______ days.

_______ (valtrex), 1000 mg. orally, ______ times daily, for _____ days.

A

Acyclovir ; five ; 5 to 7 days.

Famciclovir ; three ; seven days.

Valacyclovir ; three ; seven days.

House Microbiology (93 decks)

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