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Pharmacology > Growth Factors > Flashcards

Growth Factors Flashcards

1
Q

Epoetin Alfa Mechanism of Action

A

recombinant Erythropoietin

Stimulate red cell progenitors to make more RBC

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2
Q

Epoetin Alfa Usefulness

A

Anemia with low RBC

cancer therapy

Chronic Renal failure

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3
Q

Epoetin Alfa Side Effects

A

Hypertension

Thrombosis

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4
Q

Darbepoetin mechanism of action

A

long acting recombinant Erythropoietin

stimulates red cells to make more RBC

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5
Q

Darbepoetin Usefulness

A

anemia with low RBC

cancer therapy

Chronic Renal Failure

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6
Q

Darbepoetin Side Effects

A

Hypertension

Thrombosis

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7
Q

Filgrastim Mechanism of Action

A

G-CSF: stimulates proliferation of Neutrophil precursors

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8
Q

Filgrastim Usefulness

A

Leukopenia

reverse myelosuppression in chemo

mobilize peripheral blood stem cells for transplant

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9
Q

Filgrastim Side effects

A

bone pain

splenic rupture

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10
Q

Sargramostim Mechanism of Action

A

GM-CSF: stimulates proliferation of neutrophil precursors

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11
Q

Sargramostim Usefulness

A

leukopenia

reverse myelosuppression in chemo

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12
Q

Sargramostim Side effects

A

Fever, malaise
Arthralgias, Myalgias
Peripheral Edema
Pleural Effusions
Pericardial Effusions

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13
Q

Romiplostim Mechanism of Action

A

Thrombopoietin (TPO) Analog

Platelet Stimulator

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14
Q

Romiplostim Usefulness

A

Autoimmune Thrombocytopenia

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15
Q

Romiplostim Side Effects

A

Dizziness
Abd Pain
Myalgia
Insomnia

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16
Q

Eltrombopag Mechanism of Action

A

TPO-R Agonist

platelet Stimulator

17
Q

Eltrombopag Usefulness

A

Autoimmune Thrombocytopenia

18
Q

Eltrombopag Side effects

A

Dizziness
Abd Pain
Myalgia
Insomnia

19
Q

Hydroxyurea Mechanism of Action

A

Induce HbF

Inhibits Ribonucleoside Diphosphate Reductase

20
Q

Hydroxyurea use

A

Reduce Sickle Cell Crisis

Alter adhesion of RBC to endothelium

Treat CML

21
Q

Hydroxyurea Side Effects

A

BM Suppression

Megaloblastic Anemia

Pharmacology (18 decks)

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