Anticancer Vinca Alkaloids Flashcards
Vincristine Mechanism
Binds tubulin to block polymerization
dissolves: formes crystals with microtubules
Arrest tumor cells in M phase
M Phase inhibitors
Vincristine Use
NH: CHOP
HL
Acute lymphoblastic leukemia
solid tumors
Vincristine Side Effects
Peripheral Neuropathy
Constipation
Any Spinal Injection:100% mortality
Vinblastine Mechanism
Binds tubulin to block polymerization
dissolves: formes crystals with microtubules
Arrest tumor cells in M phase
M Phase inhibitors
Vinblastin Use
HL
Leukemias
Solid Tumors
Vinblastin Side Effects
BM depression
Paclitaxel Mechanism
Yew Alkaloid
bind beta tubulin: stabllize microtubules and block mitosis
M phase blocker
Paclitaxel Use
Breast Cancer
Ovarian cancer
Paclitaxel Side Effects
Peripheral Neuropathy
Myelosuppression (delayed)
Hypersensitivity
Alopecia
Docetaxel Mechanism
Yew Alkaloid: semi-synthetic analog paclitaxel
bind beta tubulin: stabllize microtubules and block mitosis
M phase blocker
Doxetaxel Use
Breast Cancer
Ovarian Cancer
2nd line to Paclitaxel
Doxetaxel Side Effects
Neutropenia
Anemia
Alopecia
Peripheral Neuropathy
Hypersensitivity
