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pharmacology > Anticancer Natural Products > Flashcards

Anticancer Natural Products Flashcards

1
Q

Epipodophyllotixin Drugs

A

Etopside
Teniposide

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2
Q

Etopside Mechanism

A

forms tertiary complex with Topoisomerase III: inhibiting

irreparable DNA strand breaks

block late S-G2

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3
Q

Etopside Use

A

Testicular cancer
SC Lung cancer
Leukemia
Lymphomas

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4
Q

Etopside Side Effects

A

Myelosuppression
Alopecia

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5
Q

Teniposide Mechanism

A

forms tertiary complex with Topoisomerase III: inhibiting

irreparable DNA strand breaks

block late S-G2

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6
Q

Teniposide uSe

A

Testicular cancer
SC Lung cancer
Leukemia
Lymphomas

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7
Q

Teniposide Side Effects

A

Myelosuppression
Alopecia

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8
Q

Camptothecin Drugs

A

Topetecan
Irinotecan

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9
Q

Topetecan Mechanism

A

Topoisomerase I Inhibitor

covalent complex with DNA and Topoisomerase I

prevent DNA unwinding and replication

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10
Q

Topetecan use

A

Ovarian Cancer
SC Lung Cancer

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11
Q

Topetecan Side Effects

A

Diarrhea
Immunosuppression (Neutropenia)

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12
Q

Irinotecan Mechanism

A

Topoisomerase I Inhibitor

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13
Q

Irinotecan use

A

Colon Cancer
with 5-FU and Leucovorin

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14
Q

Irinotecan Side Effects

A

Diarrhea
Immunosuppression (neutropenia)

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