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Pharmacology > Intro To Cancer Chemo: Protection from Tissue Damage > Flashcards

Intro To Cancer Chemo: Protection from Tissue Damage Flashcards

1
Q

Palifermin Mechanism

A

Recombinant Karatinocyte GF

stimulates growth and development of epithelial cells: build up mucosal barrier

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2
Q

Palifermin Use

A

Reduces incidence and duration of oral mucositis

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3
Q

Dexrazoxane Mechanism

A

Derivate of EDTA: Iron Chelator

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4
Q

Dexrazoxane Use

A

Prevent Dilated Cardiomyopathy: doxorobucin, daunorunicin

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5
Q

Amifostine Mechanism

A

Thiol Compound: Scavenges free radicals: prevents DNA Damage

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6
Q

Amifostine Use

A

Platinum compounds (cisplatin) induced nephrotoxicity

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7
Q

MESNA Mechanism

A

Sulfhydryl compound bind acrolein

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8
Q

MESNA Use

A

prevent hemorrhagic cystisis from cyclophosphamide and ifosfamide

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9
Q

Leucovorin (Folic Acid) Mechanism

A

Tetrahydrofolate Precursor

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10
Q

Leucovorin (Folic Acid) Use

A

Myelosuppression of methotrexate

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Pharmacology (18 decks)

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